Potassium two pore domain channel subfamily K member 4 is encoded by the gene KCNK4. KCNK4 is a member of the two pore domain potassium channel (TC 1.A.1.8) family. KCNK4 homodimerizes and functions as an outwardly rectifying channel. KCNK4 is regulated by polyunsaturated fatty acids, temperature, and mechanical deformation of the lipid membrane. KCNK4 is expressed in the brain, spinal cord, and eye. Diseases associated with KCNK4 include Facial Dysmorphism, Hypertrichosis, Epilepsy, Intellectual/Developmental Delay, and Gingival Overgrowth Syndrome.
Purified by Protein A chromatography
Fusion protein amino acids 256-398 (cytoplasmic C-terminus) of mouse TRAAK (accession number O88454) produced recombinantly in E. Coli
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Does not cross-react with TREK1/KCNK2
Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from date of receipt
Shipped on ice packs
Potassium channel subfamily K member 4 (TWIK-related arachidonic acid-stimulated potassium channel protein) (TRAAK)