Potassium channel subfamily K member 4 (TWIK-related arachidonic acid-stimulated potassium channel protein) (TRAAK)
Potassium two pore domain channel subfamily K member 4 is encoded by the gene KCNK4. KCNK4 is a member of the two pore domain potassium channel (TC 1.A.1.8) family. KCNK4 homodimerizes and functions as an outwardly rectifying channel. KCNK4 is regulated by polyunsaturated fatty acids, temperature, and mechanical deformation of the lipid membrane. KCNK4 is expressed in the brain, spinal cord, and eye. Diseases associated with KCNK4 include Facial Dysmorphism, Hypertrichosis, Epilepsy, Intellectual/Developmental Delay, and Gingival Overgrowth Syndrome.
Fusion protein amino acids 256-398 (cytoplasmic C-terminus) of mouse TRAAK (also known as Potassium channel subfamily K member 4, TWIK-related arachidonic acid-stimulated potassium channel protein, Two pore potassium channel KT4.1 and Kcnk4, accession number O88454); Rat: 97% identity (139/143 amino acids identical); Human: 81% identity (116/143 amino acids identical); 50% identity with TREK1/KCNK2 and other KCNK channels
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