Anti-Slc18a2/VMAT2 Antibody Biotin Conjugate (N449/73)

Name: Anti-Slc18a2/VMAT2 Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-436-BTN
Price: 543.0 USD
Availability: InStock

Our mouse Slc18a2/VMAT2 biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N449/73. It detects human, mouse, and rat Slc18a2/VMAT2 and is purified by Protein A chromatography. Works in ELISA, ICC, WB.

Anti-Slc18a2/VMAT2 Antibody Biotin Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-436-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Slc18a2/VMAT2

Scientific Background

Vesicular neurotransmitter transporters sequester the transmitters into synaptic vesicles (Erickson et al., 1996). The vesicular monoamine transporter 2 (VMAT2) is responsible for catecholamine and serotonin storage in central synapses. Antibodies specific for VMAT have been used to monitor expression of the transporter during development and in aging and can be effectively used as a marker for monoamine terminals (Haycock et al., 2003; Witkovsky et al., 2005).

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N449/73

Isotype

IgG2b

Applications

ELISA, ICC, WB

Host Species

Mouse

Gene Name

Slc18a2

Molecular Weight

60 kDa

Immunogen

Fusion Protein Amino acids 42-132 (first lumenal domain) of mouse Slc18a2 (accession number Q66L40) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

Does not cross-react with Slc18a1/VMAT1 or Slc18a3/VAChT

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

SVAT; Slc18a2 protein; VAT2; VMAT2; synaptic vesicular amine transporter; monoamine neurotransmitter transporter; monoamine transporter; solute carrier family 18 member 2; vesicle monoamine transporter type 2; vesicle monoamine/H+ antiporter; vesicular amine transporter 2

UniProt ID

Q66L40
UniProt Summary: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin. Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals. Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft. Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules.

NCBI Gene ID

6571

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Anti-Slc18a2/VMAT2 Antibody Biotin Conjugate (N449/73)

SKU: 75-436-BTN

Product Details

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