Anti-SAP102 Antibody (N19/2)

Name: Anti-SAP102 Antibody
Brand: NeuroMab
SKU: 75-058
Price: 337.0 USD
Availability: InStock

Our mouse SAP102 monoclonal antibody from NeuroMab is produced in-house from clone N19/2. It detects human, mouse, rabbit, and rat SAP102 and is purified by Protein A chromatography. KO validated. Works in WB, IHC, ICC, IP, ELISA.

Adult rat hippocampus immunohistochemistry.

Immunoblot versus adult rat brain membranes (RBM), and adult mouse hippocampal membranes (MHM) from SAP102 knockout and WT mice (mouse samples courtesy of Dr. Richard Huganir).

Coimmunofluorescence of endogenous JNK3 (green, Alexa488) with SAP102 (Cat. 75-058; magenta, Alexa568) in MAP2-positive dendrites (blue, Alexa405) of primary rat hippocampal neurons (DIV22), analyzed by confocal microscopy. Image from publication CC-BY-4.0. PMID:38582451

Western Blot image of adult mouse hippocampus screening various lysis conditions showing distinct synaptic protein solubility for GluN2B (Cat. 75-101, N59/36 ), GluA2 (75-002, L21/32), PSD-95 (75-028, K28/43), SAP102 (75-058, N19/2). Image from publication CC-BY-4.0. PMID: 39370692

Adult rat hippocampus immunohistochemistry.

Click on image to zoom

Species Reactivity

Human, Mouse, Rabbit, Rat

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

Go to Full Product Details

Data Sheet

KO Validated

SKU: 75-058

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

SAP102

Scientific Background

Synapse-Associated Protein 102, Disks large homolog 3(DLG3) or SAP102 MAGUK scaffold protein is encoded by the gene DLG3. SAP102 is a member of the MAGUK (membrane-associated guanylate kinase) protein family. SAP102 can bind to a number of adhesion molecules and receptors, including NMDA receptors and acts as a scaffold protein to mediate synaptic signaling. This protein plays a role in learning and memory and appears to be required for learning. Mutations in this gene have been associated with X-linked cognitive disability.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N19/2

Isotype

IgG1

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Dlg3 Dlgh3

Molecular Weight

105 kDa

Immunogen

Fusion protein amino acids 1-120 of rat SAP102 (accession number Q62936) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rabbit, Rat

Antibody Registry ID

AB_2261666

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Dilution Ranges

WB: 1:1000
IHC: 1:500
ICC: 1:500

Conjugate

Unconjugated

Specificity

No cross-reactivity against other MAGUK family membersPSD-95, SAP97, Chapsyn-110

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Disks large homolog 3 (PSD-95/SAP90-related protein 1) (Synapse-associated protein 102) (SAP-102) (SAP102)

UniProt ID

Q62936

Shipping

Shipped on ice packs

Recover password

Create my account

Anti-SAP102 Antibody (N19/2)

SKU: 75-058

Product Details

Bulk Order Anti-SAP102 Antibody

Related Products

Recently Viewed