Anti-Rab 9 Recombinant Chicken Chimeric mAb Biotin Conjugate (Clone 9)

Name: Anti-Rab 9 Recombinant Chicken Chimeric mAb Biotin Conjugate
Brand: Aves Labs
SKU: 78-604-BTN
Price: 562.0 USD
Availability: InStock

Our chicken Rab 9 biotin conjugate recombinant antibody from Aves Labs is produced in-house from clone Clone 9. It detects bovine, canine, hamster, human, mouse, non-human primate, and rat Rab 9 and is purified by affinity chromatography. Works in ELISA, IHC, ICC, WB, IP.

Anti-Rab 9 Recombinant Chicken Chimeric mAb Biotin Conjugate

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Species Reactivity

Bovine, Canine, Hamster, Human, Mouse, Non-Human Primate, Rat

Applications

ICC, IHC, IP, WB

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 78-604-BTN

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Rab 9

Scientific Background

Rab9 is a small GTP-binding protein of the Rab family that regulates late endosomal trafficking. It is primarily involved in the transport of mannose-6-phosphate receptor-containing vesicles from late endosomes back to the trans-Golgi network, a pathway critical for proper lysosomal enzyme sorting and recycling. Like other Rab proteins, Rab9 functions as a molecular switch, cycling between an active GTP-bound state and an inactive GDP-bound state, with its activity controlled by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Rab9-mediated trafficking ensures the steady-state distribution of cation-dependent and cation-independent mannose-6-phosphate receptors and contributes to lysosomal homeostasis. Dysregulation of Rab9 function has been linked to impaired lysosomal degradation, altered receptor recycling, and has emerging associations with cancer progression, viral infection, and lysosomal storage disorders.

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

Clone 9

Isotype

IgY

Applications

ICC, IHC, IP, WB

Gene Name

RAB9A

Molecular Weight

23 kDa

Immunogen

Recombinant canine Rab9a

Immunogen Species

Canine

Species Reactivity

Bovine, Canine, Hamster, Human, Mouse, Non-Human Primate, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone Rab9, clone 9 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone Rab9, clone 9 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Dilution Ranges

IHC: 1:50-1:200
ICC: 1:50-1:200

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

RAB9; member RAS oncogene family; rab9 GTP-binding protein; RAB9A

UniProt ID

P24408
UniProt Summary: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB9A is involved in the transport of proteins between the endosomes and the trans-Golgi network (TGN). Specifically uses NDE1/NDEL1 as an effector to interact with the dynein motor complex in order to control retrograde trafficking of RAB9-associated late endosomes to the TGN. Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.

NCBI Gene ID

403947

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Anti-Rab 9 Recombinant Chicken Chimeric mAb Biotin Conjugate (Clone 9)

SKU: 78-604-BTN

Product Details

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