Anti-M6PR Recombinant Chicken Chimeric mAb Biotin Conjugate (2G11)

Name: Anti-M6PR Recombinant Chicken Chimeric mAb Biotin Conjugate
Brand: Aves Labs
SKU: 78-603-BTN
Price: 562.0 USD
Availability: InStock

Our chicken M6PR biotin conjugate recombinant antibody from Aves Labs is produced in-house from clone 2G11. It detects bovine, human, and non-human primate M6PR and is purified by affinity chromatography. Works in ELISA, IHC, ICC, WB, IP.

Anti-M6PR Recombinant Chicken Chimeric mAb Biotin Conjugate

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Species Reactivity

Bovine, Human, Non-Human Primate

Applications

ICC, IHC, IP

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 78-603-BTN

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

M6PR

Scientific Background

The cation-independent mannose-6-phosphate receptor (CI-M6PR), also known as the insulin-like growth factor 2 receptor (IGF2R), is a large type I transmembrane glycoprotein of ~300 kDa that mediates trafficking of lysosomal hydrolases. CI-M6PR recognizes mannose-6-phosphate (M6P) tags on newly synthesized enzymes and facilitates their transport from the trans-Golgi network to endosomes, ensuring proper lysosomal function. In addition to its canonical role in lysosomal enzyme sorting, CI-M6PR regulates extracellular signaling by binding and internalizing insulin-like growth factor 2 (IGF2), thereby modulating cell growth and proliferation. Loss or dysregulation of CI-M6PR expression has been associated with impaired lysosomal biogenesis, altered growth factor signaling, and tumorigenesis, highlighting its dual role in both intracellular trafficking and growth regulation. Because of its involvement in cancer biology and lysosomal storage disorders, CI-M6PR is an important marker and functional regulator in both health and disease.

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

2G11

Isotype

IgY

Applications

ICC, IHC, IP

Host Species

Chicken

Gene Name

IGF2R

Molecular Weight

300 kDa

Immunogen

Native bovine cation independent (CI)-mannose 6-phosphate receptor

Immunogen Species

Bovine

Species Reactivity

Bovine, Human, Non-Human Primate

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone 2G11 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone 2G11 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Dilution Ranges

IHC: 1:100-1:500
ICC: 1:100-1:500

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

CI-MPR; Cation-independent mannose-6-phosphate receptor; 300 kDa mannose 6-phosphate receptor; CI Man-6-P receptor; IGF-II receptor; M6PR; MPR 300; insulin-like growth factor II receptor; insulin-like growth factor receptor type 2; Insulin-like growth factor 2 receptor; MPRI

UniProt ID

P08169
UniProt Summary: Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4.

NCBI Gene ID

281849

Shipping

Shipped on ice packs

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Anti-M6PR Recombinant Chicken Chimeric mAb Biotin Conjugate (2G11)

SKU: 78-603-BTN

Product Details

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