Anti-Neuroligin-2 Antibody Biotin Conjugate (L107/39)

Name: Anti-Neuroligin-2 Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-451-BTN
Price: 543.0 USD
Availability: InStock

Our mouse Neuroligin-2 biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone L107/39. It detects human, mouse, and rat Neuroligin-2 and is purified by Protein A chromatography. Works in ELISA, IHC, ICC, WB.

Anti-Neuroligin-2 Antibody Biotin Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-451-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Neuroligin-2

Scientific Background

Neuroligin2 is encoded by the gene NLGN2. Neuroligin2 is a transmembrane scaffolding Protein And cell adhesion molecule. It is involved in cell-cell interactions in neurons and in other cell types. It is expressed in many tissues, including the brain where it is located at the postysynaptic membrane and is involved in regulation of inhibitory synapses, synapse formation and synaptic transmission. Diseases associated with this gene include Pervasive Developmental Disorder and Autism.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

L107/39

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Nlgn2 Kiaa1366

Molecular Weight

90-100 kDa

Immunogen

Fusion Protein Amino acids 700-836 (cytoplasmic C-terminus) of mouse Neuroligin-2 (accession number Q69ZK9) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

NL2; Neuroligin-2; ortholog of human and rat neuroligin 2 NLGN2

UniProt ID

Q69ZK9
UniProt Summary: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures.

NCBI Gene ID

216856

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Anti-Neuroligin-2 Antibody Biotin Conjugate (L107/39)

SKU: 75-451-BTN

Product Details

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