Neuroligin2 is encoded by the gene NLGN2. Neuroligin2 is a transmembrane scaffolding protein and cell adhesion molecule. It is involved in cell-cell interactions in neurons and in other cell types. It is expressed in many tissues, including the brain where it is located at the postysynaptic membrane and is involved in regulation of inhibitory synapses, synapse formation and synaptic transmission. Diseases associated with this gene include Pervasive Developmental Disorder and Autism.
ICC, IHC, WB
Fusion protein amino acids 700-836 (cytoplasmic C-terminus) of mouse Neuroligin-2 (also known as Nlgn2 and Kiaa1366, accession number Q69ZK9); Rat: 100% identity (137/137 amino acids identical); Human: 99% identity (136/137 amino acids identical); 40% identity with Neuroligin-3 and other Neuroligin proteins
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.