Anti-Cytokeratin 8 Recombinant Chicken Chimeric mAb Biotin Conjugate (E8-C6-B4)

Name: Anti-Cytokeratin 8 Recombinant Chicken Chimeric mAb Biotin Conjugate
Brand: Aves Labs
SKU: 78-602-BTN
Price: 562.0 USD
Availability: InStock

Our chicken Cytokeratin 8 biotin conjugate recombinant antibody from Aves Labs is produced in-house from clone E8-C6-B4. It detects bovine and human Cytokeratin 8 and is purified by affinity chromatography. Works in ELISA, IHC, ICC, WB.

Anti-Cytokeratin 8 Recombinant Chicken Chimeric mAb Biotin Conjugate

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Species Reactivity

Bovine, Human

Applications

ICC, IHC, WB

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 78-602-BTN

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Cytokeratin 8

Scientific Background

Cytokeratin 8 (KRT8) is a type II intermediate filament protein of ~52 kDa that pairs with cytokeratin 18 to form heteropolymers in simple epithelial cells. Together, these keratins provide structural stability to epithelial tissues and contribute to cellular resilience under mechanical and apoptotic stress. Beyond their cytoskeletal role, KRT8 and KRT18 participate in intracellular signaling, apoptosis regulation, and stress response pathways. Abnormal expression or post-translational modification of KRT8 has been linked to a variety of human diseases, including chronic liver disease, inflammatory disorders, and multiple carcinomas. Because of its restricted expression in simple epithelia and frequent upregulation in tumors, KRT8 serves as both a diagnostic marker and a functional mediator of epithelial cell biology and disease progression.

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

E8-C6-B4

Isotype

IgY

Applications

ICC, IHC, WB

Host Species

Chicken

Gene Name

KRT8

Molecular Weight

52 kDa

Immunogen

C-terminal amino acids 472-483 of Human Cytokeratin 8

Immunogen Species

Human

Species Reactivity

Bovine, Human

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone E8-C6-B4 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone E8-C6-B4 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Dilution Ranges

ICC: 1:500-1:2000

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

CARD2; Keratin-8; CK8; CYK8; K2C8; keratin; type II cytoskeletal 8; cytokeratin-8; keratin 8; type II; type-II keratin Kb8; CK-8

UniProt ID

P05787
UniProt Summary: Required for the formation of KRT8/KRT18 filaments that are involved in ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement. Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

NCBI Gene ID

3856

Shipping

Shipped on ice packs

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Anti-Cytokeratin 8 Recombinant Chicken Chimeric mAb Biotin Conjugate (E8-C6-B4)

SKU: 78-602-BTN

Product Details

Bulk Order Anti-Cytokeratin 8 Recombinant Chicken Chimeric mAb Biotin Conjugate

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