Anti-Lgi1 Antibody (N283/7)

Name: Anti-Lgi1 Antibody
Brand: NeuroMab
SKU: 75-307
Price: 337.0 USD
Availability: InStock

Our mouse Lgi1 monoclonal antibody from NeuroMab is produced in-house from clone N283/7. It detects human, mouse, and rat Lgi1 and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Adult rat hippocampus immunohistochemistry under standard protocol.

Immunoblot versus whole brain homogenates (homo) from adult rat and WT and Lgi1 KO mouse probed with N283/7 TC supe. Data courtesy of Masaki Fukata (National Institute for Physiological Sciences, Japan).

Immunohistochemistry with antigen retrieval via citrate pretreatment.

Adult rat hippocampus immunohistochemistry under standard protocol.

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-307

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Lgi1

Scientific Background

Leucine Rich Glioma Inactivated 1 is encoded by the gene LGI1. LGI1 is a member of the secreted leucine-rich repeat (LRR) superfamily. LGI1 may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. LGI1 is expressed in the brain. Diseases associated with LGI1 include Epilepsy, Familial Temporal Lobe, 1 and Autosomal Dominant Epilepsy with Auditory Features.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N283/7

Isotype

IgG2a

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Lgi1

Molecular Weight

60 kDa

Immunogen

Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse Lgi1 (accession number Q9JIA1) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2315876

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with Lgi2, Lgi3 or Lgi4 (based on KO validation results)

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Leucine-rich glioma-inactivated protein 1

UniProt ID

Q9JIA1

Shipping

Shipped on ice packs

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Anti-Lgi1 Antibody (N283/7)

SKU: 75-307

Product Details

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