Anti-GAD65/67 Recombinant Chicken Chimeric mAb Biotin Conjugate (L127/12)

Name: Anti-GAD65/67 Recombinant Chicken Chimeric mAb Biotin Conjugate
Brand: Aves Labs
SKU: 78-508-BTN
Price: 562.0 USD
Availability: InStock

Our chicken GAD65/67 biotin conjugate recombinant antibody from Aves Labs is produced in-house from clone L127/12. It detects human, mouse, and rat GAD65/67 and is purified by affinity chromatography. Works in ELISA, ICC, IHC, WB.

Anti-GAD65/67 Recombinant Chicken Chimeric mAb Biotin Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

AT, ELISA, ICC, IHC, WB

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

Trial Size

SKU: 78-508-BTN

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

GAD65/67

Scientific Background

There are two forms of the enzyme glutamic-acid decarboxylase (GAD), a 65-kDa form (GAD65) and a 67-kDa form (GAD67) which are the result of the expression of different genes. Further splicing of GAD 67 produces one or two smaller variants, including GAD25 and GAD44. GAD67 and GAD65 are expressed in adult brain and the pancreas. The truncated forms GAD25 and GAD44 are expressed during embryonic development. Glutamic acid decarboxylase enzyme functions to catalyze the production of gamma-aminobutyric acid from L-glutamic acid.

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

L127/12

Isotype

IgY

Applications

AT, ELISA, ICC, IHC, WB

Host Species

Chicken

Gene Name

GAD1, GAD, GAD67

Molecular Weight

70 kDa

Immunogen

Fusion Protein Amino acids 1-594 (full-length) of human GAD67 (accession number Q99259) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone L127/12 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone L127/12 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Dilution Ranges

IHC: 1:100
ICC: 1:100

Conjugate

Biotin

Specificity

Cross-reacts with GAD25, GAD44 and GAD65/GAD2

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

CPSQ1; GAD67; SCP; glutamate decarboxylase 1; 67 kDa glutamic acid decarboxylase; GAD-67; glutamate decarboxylase 1 (brain; 67kDa; glutamate decarboxylase 67 kDa isoform; GAD1; GAD and DCE1

UniProt ID

Q99259
UniProt Summary: Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.

NCBI Gene ID

2571

Shipping

Shipped on ice packs

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Anti-GAD65/67 Recombinant Chicken Chimeric mAb Biotin Conjugate (L127/12)

SKU: 78-508-BTN

Product Details

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