Anti-GABA-A-R-Pi Antibody Biotin Conjugate (N431/64)

Name: Anti-GABA-A-R-Pi Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-419-BTN
Price: 543.0 USD
Availability: InStock

Our mouse GABA-A-R-Pi biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N431/64. It detects human and rat GABA-A-R-Pi and is purified by Protein A chromatography. Works in ELISA, ICC, WB.

Anti-GABA-A-R-Pi Antibody Biotin Conjugate

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Species Reactivity

Human, Rat

Applications

ELISA, ICC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-419-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

GABA-A-R-Pi

Scientific Background

Gamma-aminobutyric acid receptor subunit pi or GABA AR Pi is encoded by the gene GABRP. GABA A receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR pi is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR Pi has been found in tissues including the uterus, ovaries lung, thymus and prostate.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N431/64

Isotype

IgG2a

Applications

ELISA, ICC, WB

Host Species

Mouse

Gene Name

GABRP

Molecular Weight

45 kDa

Immunogen

Fusion Protein Amino acids 22-242 (extracellular N-terminus) of human GABA-A receptor Pi (accession number O00591) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

Does not cross-react with GABAARDelta

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

gamma-aminobutyric acid receptor subunit pi; GABA(A receptor; GABA(A receptor subunit pi; gamma-aminobutyric acid (GABA A receptor

UniProt ID

O00591
UniProt Summary: Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces. When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Pi-containing GABAARs are mostly located in peripheral tissues. In the uterus, pi subunits modulate uterus contraction by altering the sensitivity of GABAARs to pregnanolone. In the lungs, pi-containing GABAARs contribute to pulmonary fluid transport via luminal secretion of chloride.

NCBI Gene ID

2568

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Anti-GABA-A-R-Pi Antibody Biotin Conjugate (N431/64)

SKU: 75-419-BTN

Product Details

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