Anti-Cavbeta1 Ca2+ Channel Antibody (N7/18)

Name: Anti-Cavbeta1 Ca2+ Channel Antibody
Brand: NeuroMab
SKU: 75-052
Price: 337.0 USD
Availability: InStock

Our mouse Cavbeta1 Ca2+ channel monoclonal antibody from NeuroMab is produced in-house from clone N7/18. It detects human, mouse, non-human primate, and rat Cavbeta1 Ca2+ channel and is purified by Protein A chromatography. Works in WB, IHC, ICC, IP, ELISA.

Adult rat hippocampus immunohistochemistry.

Adult rat whole brain immunohistochemistry.

$Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with N7/18 (left) or N52A/42 (right) TC supe.$

When coexpressed with CaV1.1 in F8 (CaV1.1−/−, STAC3−/−) myotubes, STAC3-ETLAAA-GFP does not colocalize in clusters with the β1 subunit, contrary to wild-type STAC3-GFP. Image from publication CC-BY-4.0. PMID:36161458

Adult rat hippocampus immunohistochemistry.

Click on image to zoom

Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-052

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Cavbeta1 Ca2+ channel

Scientific Background

Voltage-dependent L-type calcium channel subunit beta-1 or Cav ß1 is encoded by the gene CACNB1. Cavß1 is a cytoplasmic subunit of L type voltage-sensitive calcium channels. These channels facilitate entry of calcium ions into excitable cells are involved in a variety of calcium dependent processes, including neurotransmitter release, muscle contraction, and gene expression. Cavß1 serves to regulate the activity of L-type calcium channels. Cavß1 expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Diseases associated with CACNB1 include Malignant Hyperthermia and epileptic encephalopathy.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N7/18

Isotype

IgG2a

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

CACNB1 CACNLB1

Molecular Weight

80, 55 kDa

Immunogen

Synthetic peptide amino acids 19-34 of human Cav1 (PMEVFDPSPQGKYSKR; accession number NP_059042)

Immunogen Species

Human

Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Antibody Registry ID

AB_2243972

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Dilution Ranges

WB: 1:1000
IHC: 1:2000
ICC: 1:2000

Conjugate

Unconjugated

Specificity

Does not cross-react with Cavβ2, Cavβ3, Cavβ4

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Voltage-dependent L-type calcium channel subunit beta-1 (CAB1) (Calcium channel voltage-dependent subunit beta 1)

UniProt ID

Q02641

Shipping

Shipped on ice packs

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Anti-Cavbeta1 Ca2+ Channel Antibody (N7/18)

SKU: 75-052

Product Details

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