Anti-Cav1.3 Ca2+ Channel Antibody (N38/8)

Name: Anti-Cav1.3 Ca2+ Channel Antibody
Brand: NeuroMab
SKU: 75-080
Price: 337.0 USD
Availability: InStock

Our mouse Cav1.3 Ca2+ channel monoclonal antibody from NeuroMab is produced in-house from clone N38/8. It detects human, mouse, and rat Cav1.3 Ca2+ channel and is purified by Protein A chromatography. Works in WB, IHC, ICC, PLA, ELISA.

Immunostaining of mouse brain cortex identifying the calcium channels along axons stained with Anti-Cav1.3 Ca2+ Channel Antibody (Cat. 75-080, 1:500, green) and nuclei are labeled with DAPI (blue). Image kindly provided by Kaveh Moradi, Virginia Commonwealth University.

Adult rat hippocampus immunohistochemistry.

Immunostaining of mouse brain cortex identifying the calcium channels along axons stained with Anti-Cav1.3 Ca2+ Channel Antibody (Cat. 75-080, 1:500, green) and nuclei are labeled with DAPI (blue). Image kindly provided by Kaveh Moradi, Virginia Commonwealth University.

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-080

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Cav1.3 Ca2+ channel

Scientific Background

Voltage-dependent L-type calcium channel subunit alpha-1D, or Cav1.3 calcium channel is a calcium channel encoded by the gene CACNA1D. It is a member of the L type voltage dependent calcium channel family. These calcium channels mediate the influx of calcium ions into a cell upon membrane polarization. Cav1.3 is expressed primarily in the membrane of the heart, brain (cerebral cortex, hippocampus, basal ganglia and thalamus). and pancreatic islets. Calcium channels are involved in many cell processes including muscle contraction, neurotransmitter release, gene expression, cell division and cell death. Diseases associated with Cav1.3 include Primary Aldosteronism, Seizures, Sinoatrial Node Dysfunction and Deafness.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N38/8

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Cacna1d Cach3 Cacn4 Cacnl1a2 Cchl1a2

Molecular Weight

>220 kDa

Immunogen

Fusion protein amino acids 2025-2161 (C-terminus) of rat Cav1.3 (accession number P27732) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_10673964

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.10

Dilution Ranges

WB: 1:1000
IHC: 1:100
ICC: 1:100

Conjugate

Unconjugated

Specificity

Does not cross-react with Cav1.2

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2) (Rat brain class D) (RBD) (Voltage-gated calcium channel subunit alpha Cav1.3)

UniProt ID

P27732

Shipping

Shipped on ice packs

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Anti-Cav1.3 Ca2+ Channel Antibody (N38/8)

SKU: 75-080

Product Details

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