Anti-Cav alpha2 delta2 Recombinant Chicken Chimeric mAb FL594 Conjugate (N492/39)

Name: Anti-Cav alpha2 delta2 Recombinant Chicken Chimeric mAb FL594 Conjugate
Brand: Aves Labs
SKU: 78-530-FL594
Price: 562.0 USD
Availability: InStock

Our chicken Anti-Cav alpha2 delta2 FL594 conjugate recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N492/39. It detects human, mouse, and rat Cav alpha2 delta2 and is purified by affinity chromatography. Works in ICC, IHC.

Anti-Cav alpha2 delta2 Recombinant Chicken Chimeric mAb FL594 Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

650

Biotin

Carrier-Free

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Data Sheet

SKU: 78-530-FL594

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Cav alpha2 delta2

Scientific Background

Cav α2δ2 is an auxiliary subunit of voltage-gated calcium channels that modulates channel trafficking, gating, and pharmacological properties. Encoded by the CACNA2D2 gene, this glycoprotein is synthesized as a single precursor that is post-translationally cleaved into the extracellular α2 and membrane-anchored δ2 subunits, linked by disulfide bonds. Cav α2δ2 enhances calcium current density by promoting the proper trafficking of pore-forming Cavα1 subunits to the plasma membrane and stabilizing them at synaptic sites. It plays a key role in neurotransmitter release, synaptic plasticity, and neuronal excitability. Altered expression or mutation of CACNA2D2 has been associated with neurological disorders, including epilepsy, cerebellar ataxia, and certain cancers, underscoring its importance in calcium channel regulation and disease pathophysiology.

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

N492/39

Isotype

IgY

Applications

ICC, IHC

Host Species

Chicken

Gene Name

Cacna2d2

Molecular Weight

130 kDa

Excitation / Emission

FL594 Ex: 594 nm, Em: 615 nm

Immunogen

Recombinant protein amino acids 61-197 (extracellular domain) of mouse Cav alpha2 delta2 (also known as voltage-dependent R-type calcium channel subunit alpha-2/delta-2, Cacna2d2, accession number Q6PHS9) produced recombinantly in E.Coli.

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N492/39 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N492/39 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Conjugate

594

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

voltage-dependent R-type calcium channel subunit alpha-2/delta-2, Cacna2d2

Shipping

Shipped on ice packs

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Anti-Cav alpha2 delta2 Recombinant Chicken Chimeric mAb FL594 Conjugate (N492/39)

SKU: 78-530-FL594

Product Details

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