Anti-Cav alpha2 delta2 Recombinant Chicken Chimeric mAb (N492/39)

Name: Anti-Cav alpha2 delta2 Recombinant Chicken Chimeric mAb
Brand: Aves Labs
SKU: 78-530
Price: 470.0 USD
Availability: InStock

Our chicken Anti-Cav alpha2 delta2 recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N492/39. It detects human, mouse, and rat Cav alpha2 delta2, and is purified by affinity chromatography. It is great for use in ELISA, ICC, IHC, WB.

Representative image of formalin fixed paraffin embedded section
of rat cerebellum section stained with Aves Labs anti-Cavα2δ2 recombinant chicken monoclonal antibody (brown, Cat No. 78-530) and counterstained with hematoxylin (blue). Anti-Cavα2δ2 specifically stains the Purkinje cells in the cerebellum.

Western blotting of rat brain membrane with anti-Cavα2δ2 recombinant chicken mAb (Cat No. 78-503) antibody, recognizing endogenous Cavα2δ2 at ~130 kDa, and detected with anti-chicken-HRP (Cat No. 80-1000-HRP).

Immunohistochemistry staining of cerebellum region from adult rats using anti-Cavα2δ2 NeuroMab mouse monoclonal antibody (Clone N492/39). The variable region of this antibody was used to generate the recombinant chicken chimeric anti-Cavα2δ2 antibody (78-530).

Representative image of formalin fixed paraffin embedded section of rat cerebellum section stained with Aves Labs anti-Cavα2δ2 recombinant chicken monoclonal antibody (brown, Cat No. 78-530) and counterstained with hematoxylin (blue). Anti-Cavα2δ2 specifically stains the Purkinje cells in the cerebellum.

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Conjugates and Formulations

490

550

594

650

Carrier-Free

Go to Full Product Details

Data Sheet

Trial Size

SKU: 78-530

Volume: 100 µL

Variant

Price:

$470.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Cav alpha2 delta2

Scientific Background

Cav α2δ2 is an auxiliary subunit of voltage-gated calcium channels that modulates channel trafficking, gating, and pharmacological properties. Encoded by the CACNA2D2 gene, this glycoprotein is synthesized as a single precursor that is post-translationally cleaved into the extracellular α2 and membrane-anchored δ2 subunits, linked by disulfide bonds. Cav α2δ2 enhances calcium current density by promoting the proper trafficking of pore-forming Cavα1 subunits to the plasma membrane and stabilizing them at synaptic sites. It plays a key role in neurotransmitter release, synaptic plasticity, and neuronal excitability. Altered expression or mutation of CACNA2D2 has been associated with neurological disorders, including epilepsy, cerebellar ataxia, and certain cancers, underscoring its importance in calcium channel regulation and disease pathophysiology.

Format

Purified by affinity chromatography

Concentration

1 mg/mL

Clonality

Recombinant

Clone

N492/39

Isotype

IgY

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Gene Name

Cacna2d2

Molecular Weight

130 kDa

Excitation / Emission

Unconjugated

Immunogen

Recombinant protein amino acids 61-197 (extracellular domain) of mouse Cav alpha2 delta2 (also known as voltage-dependent R-type calcium channel subunit alpha-2/delta-2, Cacna2d2, accession number Q6PHS9) produced recombinantly in E.Coli.

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions clone N492/39 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N492/39 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Dilution Ranges

WB: 1:1000
WB Brain: 1:1000
IHC: 1:250

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

voltage-dependent R-type calcium channel subunit alpha-2/delta-2, Cacna2d2

Shipping

Shipped on ice packs

Recover password

Create my account

Anti-Cav alpha2 delta2 Recombinant Chicken Chimeric mAb (N492/39)

SKU: 78-530

Product Details

Bulk Order Anti-Cav alpha2 delta2 Recombinant Chicken Chimeric mAb

Related Products

Recently Viewed