Anti-Cav1.2 Ca2+ Channel Recombinant Chicken Chimeric mAb Biotin Conjugate (N500/4)

Name: Anti-Cav1.2 Ca2+ Channel Recombinant Chicken Chimeric mAb Biotin Conjugate
Brand: Aves Labs
SKU: 78-535-BTN
Price: 562.0 USD
Availability: InStock

Our chicken Cav1.2 Ca2+ Channel biotin conjugate recombinant antibody from Aves Labs is produced in-house from clone N500/4. It detects human, mouse, and rat Cav1.2 Ca2+ Channel and is purified by affinity chromatography. Works in ELISA, ICC, IHC, WB.

Anti-Cav1.2 Ca2+ Channel Recombinant Chicken Chimeric mAb Biotin Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

Trial Size

SKU: 78-535-BTN

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Cav1.2 Ca2+ Channel

Scientific Background

Cav1.2 is the pore-forming subunit of the L-type voltage-gated calcium channel (VGCC). The necessity of calcium for heart contraction was identified in the 1880s, it wasn't until the late 1980s that the CACNA1C gene encoding Cav1.2 was successfully cloned and characterized. Cav1.2 is a "molecular transducer" that converts electrical signals into chemical actions. It is most prominent in cardiac and smooth muscle, as well as in neurons. When the cell membrane depolarizes, Cav1.2 undergoes a conformational change to allow Ca2+ ions to flow into the cytoplasm. In the heart, this influx is the first step for excitation-contraction coupling, as it triggers the RyR2 receptors to release the bulk of the calcium needed for a heartbeat. In the brain, Cav1.2-mediated calcium entry is vital for Long-Term Potentiation (LTP) and gene expression. Dysfunction in Cav1.2 is clinically linked to Timothy Syndrome, a severe multisystem disorder characterized by cardiac arrhythmias and autism.

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

N500/4

Isotype

IgY

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Gene Name

Cacna1c

Molecular Weight

240 kDa

Immunogen

Recombinant Protein Amino acids 785-900 (ID I-II cytoplasmic loop) of mouse Cav1.2 (also known as voltage-dependent L-type calcium channel subunit alpha-1C, Cacna1c, accession number Q01815) produced recombinantly in E. Coli.

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N500/4 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N500/4 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Dilution Ranges

IHC: 1:100-1:500
ICC: 1:100-1:500

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

brain class C; voltage-dependent L-type calcium channel subunit alpha-1C; Cav1.2; D930026N18Rik; MBC; MELC-CC; calcium channel voltage-dependent alpha1c subunit; skeletal muscle-specific calcium channel; voltage-gated calcium channel subunit alpha Cav1.2; Cacna1c

UniProt ID

Q01815
UniProt Summary: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).

NCBI Gene ID

12288

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Anti-Cav1.2 Ca2+ Channel Recombinant Chicken Chimeric mAb Biotin Conjugate (N500/4)

SKU: 78-535-BTN

Product Details

Bulk Order Anti-Cav1.2 Ca2+ Channel Recombinant Chicken Chimeric mAb Biotin Conjugate

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