Anti-CALB1/Calbindin Recombinant Chicken Chimeric mAb Biotin Conjugate (L109/57)

Name: Anti-CALB1/Calbindin Recombinant Chicken Chimeric mAb Biotin Conjugate
Brand: Aves Labs
SKU: 78-448-BTN
Price: 562.0 USD
Availability: InStock

Our chicken CALB1/calbindin biotin conjugate recombinant antibody from Aves Labs is produced in-house from clone L109/57. It detects human, mouse, and rat CALB1/calbindin and is purified by affinity chromatography. Works in ELISA, ICC, IHC, WB.

Anti-CALB1/Calbindin Recombinant Chicken Chimeric mAb Biotin Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

AT, ELISA, ICC, IHC, WB

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

Trial Size

SKU: 78-448-BTN

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

CALB1/calbindin

Scientific Background

Calbindin (aka. calbindin D28k) is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. It is predominantly expressed in certain types of neurons, particularly in dendrites and perikarya of the cerebellum and is thought to buffer entry of calcium upon stimulation of glutamate receptors (Andressen et al., 1993). Calbindin has recently been shown to play a critical role in mitochondrial dysfunction and loss of synaptic proteins in vivo in an Alzheimer’s disease mouse model (Kook et al., 2014).

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

L109/57

Isotype

IgY

Applications

AT, ELISA, ICC, IHC, WB

Host Species

Chicken

Gene Name

CALB1 CAB27

Molecular Weight

30 kDa

Immunogen

Fusion Protein Amino acids 1-261 (full-length) of human CALB1 (accession number P05937) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of our NeuroMab clone L109/57 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone L109/57 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

avian-type antibody; Calbindin; CAB27 antibody; Calbindin D28; CALB 1 antibody; D-28K; CALB antibody; Vitamin D-dependent calcium-binding protein; CALB1 antibody; CALB1_HUMAN antibody; Calbindin 1 28kDa antibody; Calbindin antibody; Calbindin D28 antibody; D 28K antibody; D-28K antibody; D28K antibody; OTTHUMP00000166027 antibody; OTTHUMP00000225441 antibody; RTVL H protein antibody; Vitamin D dependent calcium binding protein antibody; Vitamin D dependent calcium binding protein avian type antibody; Vitamin D-dependent calcium-binding protein antibody; avian-type

UniProt ID

P05937
UniProt Summary: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

NCBI Gene ID

793

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Anti-CALB1/Calbindin Recombinant Chicken Chimeric mAb Biotin Conjugate (L109/57)

SKU: 78-448-BTN

Product Details

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