Anti-BDNF Antibody (N450/53)

Name: Anti-BDNF Antibody
Brand: NeuroMab
SKU: 75-470
Price: 337.0 USD
Availability: InStock

Our mouse BDNF monoclonal antibody from NeuroMab is produced in-house from clone N450/53. It detects mouse and rat BDNF and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Immunofluorescence labeling of adult rat hippocampus with N450/53 TC supe (red) and Hoechst nuclear stain (blue).

Immunofluorescence labeling of adult rat hippocampus with N450/53 TC supe (red) and Hoechst nuclear stain (blue).

Click on image to zoom

Species Reactivity

Mouse, Rat

Applications

ELISA, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-470

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

BDNF

Scientific Background

Brain-derived neurotrophic factor is encoded by the gene BDNF and is a member of the neurotrophin family of growth factors. BDNF is a secreted signaling molecule with may important functions including axonal growth, modulation of dendritic growth, the promotion of survival/differentiation of neuronal populations in peripheral and central nervous systems, regulation of synaptic transmission/plasticity and long-term potentiation. BDNF is expressed highly in brain (in the hippocampus, amygdala, cerebral cortex and cerebellum) and expressed in lung, heart and skeletal muscle. Diseases associated with this gene include Congenital Central Hypoventilation Syndrome, Wilms Tumor, Aniridia and Mental Retardation Syndrome.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N450/53

Isotype

IgG2b

Applications

ELISA, IHC, WB

Host Species

Mouse

Gene Name

Bdnf

Molecular Weight

25-40 kDa

Immunogen

Fusion protein amino acids 1-249 (full length) of mouse BDNF (accession number P21237) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2722670

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Brain-derived neurotrophic factor (Abrineurin)

UniProt ID

P21237

Shipping

Shipped on ice packs

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Anti-BDNF Antibody (N450/53)

SKU: 75-470

Product Details

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