Anti-Arl13b Recombinant Guinea Pig Chimeric mAb Biotin Conjugate (N295B/66)

Name: Anti-Arl13b Recombinant Guinea Pig Chimeric mAb Biotin Conjugate
Brand: Antibodies Incorporated
SKU: 74-287-BTN
Price: 562.0 USD
Availability: InStock

Our guinea pig Arl13b biotin conjugate recombinant antibody from Antibodies Incorporated is produced in-house from clone N295B/66. It detects human, mouse, non-human primate, rat, and zebrafish Arl13b and is purified by affinity chromatography. KO validated. Works in ELISA, ICC, IHC, WB.

Anti-Arl13b Recombinant Guinea Pig Chimeric mAb Biotin Conjugate

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Species Reactivity

Human, Mouse, Non-Human Primate, Rat, Zebrafish

Applications

ELISA, ICC, IHC, WB

Host Species

Guinea Pig

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Trial Size

SKU: 74-287-BTN

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Arl13b

Scientific Background

ADP-ribosylation factor-like protein 13B (ARL13B), also known as ADP-ribosylation factor-like protein 2-like 1. Arl13B is a small GTPase with both N-terminal and C-terminal guanine nucleotide-binding motifs. Arl13B is localized to the membrane of cilia and expressed in Neuroepithelial cells and developing radial glia of the developing cerebral cortex. Mutations in this gene are the cause of Joubert syndrome 8.

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

N295B/66

Isotype

IgG

Applications

ELISA, ICC, IHC, WB

Host Species

Guinea Pig

Gene Name

Arl13b Arl2l1

Molecular Weight

50 kDa

Immunogen

Fusion Protein Amino acids 208-427 (C-terminus) of mouse Arl13b (accession number Q640N2) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Non-Human Primate, Rat, Zebrafish

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N295B/66 with guinea pig IgG heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N295B/66 but can be detected using standard anti-guinea pig secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Conjugate

Biotin

Specificity

Does not cross-react with Arl13a (based on KO validation results)

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

A530097K21Rik; ADP-ribosylation factor-like protein 13B; Arl2l1; ADP-ribosylation factor-like protein 2-like 1; C530009C10Rik; ARL2-like protein 1; hnn; Protein hennin; ADP-ribosylation factor-like 2-like 1

UniProt ID

Q640N2
UniProt Summary: Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. Plays a role in ciliar trafficking of phosphatidylinositol phosphatase INPP5E in ciliogenesis. May regulate ARF6- and RAB22A-dependent endocytic recycling traffic.

NCBI Gene ID

68146

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Anti-Arl13b Recombinant Guinea Pig Chimeric mAb Biotin Conjugate (N295B/66)

SKU: 74-287-BTN

Product Details

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