Anti-Alpha Synuclein Antibody FL490 Conjugate (6113-62)

Name: Anti-Alpha Synuclein Antibody FL490 Conjugate
Brand: Antibodies Incorporated
SKU: 77-521-FL490
Price: 486.0 USD
Availability: InStock

Our mouse Alpha-Synuclein FL490 conjugate monoclonal antibody from Antibodies Incorporated is produced in-house from clone 6113-62. It detects human, mouse, non-human primate, and rat Alpha-Synuclein and is purified by Protein A chromatography. Works in IHC, ICC.

Anti-Alpha Synuclein Antibody FL490 Conjugate

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Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

550

594

650

Biotin

Carrier-Free

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Data Sheet

KO Validated

SKU: 77-521-FL490

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Alpha-Synuclein

Scientific Background

Alpha-synuclein (SNCA), also known as PARK1, NACP, PARK4, is a member of the synuclein family, which also includes beta- and gamma-synuclein. Alpha-synuclein is a highly conserved protein known to be abundant in neurons and especially presynaptic terminals where it serves multiple roles including regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Functionally, alpha-synuclein has been implicated in synaptic plasticity (Liu 2004) and the assembly of snare complexes (Burre 2010) and it is known to be associated with various neuropathologies including Parkinson's Disease, Lewy Body Dementia, and Alzheimer's Disease, where it forms insoluble protein aggregates. Early studies of amyloid deposits in the brains of Alzheimer's patients revealed two previously uncharacterized peptides in addition to the amyloid beta fragment (Ueda 1993), both of which were found to correspond to alpha-synuclein (SNCA). Later studies confirmed that aggregated alpha-synuclein proteins are present in brain lesions (Lewy bodies) that are hallmarks of neurodegenerative synucleinopathies and that alpha-synuclein likely plays a role in the pathogenesis of Parkinson's disease, Lewy body dementia, and Alzheimer’s disease among other neuropathologies. The SNCA antibody was raised against full-length human alpha-synuclein and recognizes endogenous levels of alpha-synuclein in brain by Western blot and immunohistochemistry.

Format

Purified by Protein A Chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

6113-62

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

SNCA

Molecular Weight

18 kDa

Immunogen

Full length human alpha-synuclein (accession number P37840) produced recombinantly in E. coli.

Immunogen Species

Human

Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Antibody Registry ID

AB_2940708

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used in Western blot on lysate from rat whole brain.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

NACP, PARK1

UniProt ID

P37840

Shipping

Shipped on ice packs

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Anti-Alpha Synuclein Antibody FL490 Conjugate (6113-62)

SKU: 77-521-FL490

Product Details

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