Anti-TRPM8 Antibody

Name: Anti-TRPM8 Antibody
Brand: PhosphoSolutions
SKU: 24282
Price: 456.0 USD
Availability: InStock

Our TRPM8 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human TRPM8 and is antigen affinity purified. It is great for use in WB.

Immunohistochemistry of Formalin-Fixed Paraffin-Embedded (FFPE) prostate cancer cells showing specific staining of TRPM8.

Western Blot of transfected COS cells showing specific immunolabeling of TRPM8.

Immunohistochemistry of Formalin-Fixed Paraffin-Embedded (FFPE) prostate cancer cells showing specific staining of TRPM8.

Click on image to zoom

Species Reactivity

Human

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 24282

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

TRPM8

Scientific Background

A novel gene, trp-p8 has an expression pattern within normal human tissues that is mostly restricted to prostate epithelial cells. Trp-p8 mRNA expression is at moderate levels in normal prostate tissue and appears to be elevated in prostate cancer. Notably, trp-p8 mRNA was also expressed in a number of nonprostatic primary tumors of breast, colon, lung, and skin origin, whereas transcripts encoding trp-p8 were hardly detected or not detected in the corresponding normal human tissues.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

TRPM8

Immunogen

Synthetic peptide corresponding to amino acids from the C-terminal region of human TRPMs protein

Immunogen Species

Human

Species Reactivity

Human

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the C-terminal region of human TRPMs protein

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

LTRPC6; Transient receptor potential cation channel subfamily M member 8; TRPP8; trp-p8; TRPM8 cationic channel; transient receptor potential p8; transient receptor potential subfamily M member 8; Long transient receptor potential channel 6

UniProt ID

Q7Z2W7
UniProt Summary: Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin therefore plays a central role in the detection of environmental cold temperatures. TRPM8 is a voltage-dependent channel; its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel. In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality. May plays a role in prostate cancer cell migration.

NCBI Gene ID

79054

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Anti-TRPM8 Antibody

SKU: 24282

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