Anti-PTCH1 Antibody

Name: Anti-PTCH1 Antibody
Brand: PhosphoSolutions
SKU: 24134
Price: 456.0 USD
Availability: InStock

Our PTCH1 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects mouse PTCH1 and is antigen affinity purified. It is great for use in WB.

Immunocytochemistry of fibroblasts and oral squamous carcinoma cells showing specific immunolableing of Patched 1/PTCH Antibody in upper right. Magnification: 400x. Image from the following publication (//pubmed.ncbi.nlm.nih.gov/32899449/) licensed under a CC-BY license.

Immunohistochemistry showing specific staining of PTCH1 and increased protein levels throughout the growth plate in Smad2 and Smad3 mutants, particularly in the resting zone. All images are P0 proximal tibias. Image from the following publication (http://dx.plos.org/10.1371/journal.pgen.1006352) licensed under a CC-BY license.

Western Blot of human fetal brain lysate showing specific immunolabeling of PTCH1.

Immunocytochemistry of fibroblasts and oral squamous carcinoma cells showing specific immunolableing of Patched 1/PTCH Antibody in upper right. Magnification: 400x. Image from the following publication (//pubmed.ncbi.nlm.nih.gov/32899449/) licensed under a CC-BY license.

Click on image to zoom

Species Reactivity

Chicken, Human, Mouse, Rat

Applications

ELISA, WB

Host Species

Rabbit

Go to Full Product Details

Data Sheet

SKU: 24134

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

PTCH1

Scientific Background

Mutations of the human Patched tumor suppressor gene (PTCH) have been identified in individuals with the nevoid basal cell carcinoma syndrome (NBCCS) as well as in sporadic basal cell carcinomas and medulloblastomas.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

PTCH1

Immunogen

Synthetic peptide corresponding to amino acids from mouse PTCH1 protein

Immunogen Species

Mouse

Species Reactivity

Chicken, Human, Mouse, Rat

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with mouse PTCH protein. Expected to cross react with rat, chicken and human due to 100% sequence identity.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

A230106A15Rik; Patched; Ptc1; Ptch; mes; wig; protein patched homolog 1; Ptch1 protein +12b; mesenchymal dysplasia; patched homolog 1; BCNS; Holoprosencephaly 7; HPE7; NBCCS; PTCH protein; PTC

UniProt ID

Q61115
UniProt Summary: Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.

NCBI Gene ID

19206

Shipping

Blue Ice

Recover password

Create my account

Anti-PTCH1 Antibody

SKU: 24134

Product Details

Bulk Order Anti-PTCH1 Antibody

Related Products

Recently Viewed