Anti-NGFR/p75 neurotrophin receptor (p75NTR) Antibody

Name: Anti-NGFR/p75 neurotrophin receptor (p75NTR) Antibody
Brand: Biosensis
SKU: R-089-100
Price: 337.0 USD
Availability: InStock

Our Anti-NGFR/p75 neurotrophin receptor (p75NTR) rabbit polyclonal primary antibody detects human and rat NGFR/p75 neurotrophin receptor (p75NTR), and is whole serum. It is validated for use in ICC, IHC-Frozen.

IHC on rat spinal cord (free floating cryo section) using Rabbit antibody to recombinant human p75NTR: whole serum (R-089-100) at a dilution of 1: 1000.

IHC on rat trigeminal nerve (free floating cryo section) using Rabbit antibody to recombinant human p75NTR: whole serum (R-089-100) at a dilution of 1: 1000.

IHC on rat spinal cord (free floating cryo section) using Rabbit antibody to recombinant human p75NTR: whole serum (R-089-100) at a dilution of 1: 1000.

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Species Reactivity

Human, Rat

Applications

ICC, IHC

Host Species

Rabbit

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Data Sheet

SKU: R-089-100

Volume/Size: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

NGFR/p75 neurotrophin receptor (p75NTR)

Scientific Background

FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. DOMAIN: Death domain is responsible for interaction with RANBP9. PTM: N- and O-glycosylated. PTM: O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. PTM: Phosphorylated on serine residues. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 4 TNFR-Cys repeats.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

ICC, IHC

Host Species

Rabbit

Immunogen

Extra cellular domain of human p75NTR

Immunogen Species

Human

Species Reactivity

Human, Rat

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Dilution Ranges

IHC: 1:500-1:2000

Conjugate

Unconjugated

Specificity

IHC shows specific staining for p75NTR. This antibody is known to react to rat p75NTR.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

CD271; Low-affinity nerve growth factor receptor; p75(NTR; NGF receptor; TNFR superfamily; Gp80-LNGFR; member 16; p75 ICD; Low affinity neurotrophin receptor p75NTR; CD271 antigen; p75NTR; TNFRSF16

UniProt ID

P08138
UniProt Summary: Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF. Plays an important role in differentiation and survival of specific neuronal populations during development. Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA. Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. Together with BFAR negatively regulates NF-kappa-B and JNK-related signaling pathways.

NCBI Gene ID

4804

Shipping

25°C (ambient)

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Anti-NGFR/p75 neurotrophin receptor (p75NTR) Antibody

SKU: R-089-100

Product Details

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