Anti-GDNF family receptor alpha-4 (GFR alpha-4) Antibody

Name: Anti-GDNF family receptor alpha-4 (GFR alpha-4) Antibody
Brand: Biosensis
SKU: C-1662-100
Price: 467.0 USD
Availability: InStock

Our Anti-GDNF family receptor alpha-4 (GFR alpha-4) chicken polyclonal primary antibody detects human GDNF family receptor alpha-4 (GFR alpha-4), and is affinity-purified. It is validated for use in IHC-Frozen, WB.

Western-Blot detection of human GFRα-4, using Chicken polyclonal antibody to human GFRα-4. GFRα-4 was expressed by CHO cell culture. 100 ng of purified protein was loaded per lane. Line 1. hGFRα-4. Primary antibody dilution 1:5000 was used. Line 2. Prestained protein ladder (Naxo 8003).

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Species Reactivity

Human

Applications

IHC, WB

Host Species

Chicken

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Data Sheet

SKU: C-1662-100

Volume/Size: 100 µL

Variant

Price:

$467.00

Quantity:

Ships: 1-2 business days

Product Details

Target

GDNF family receptor alpha-4 (GFR alpha-4)

Scientific Background

GFRa-4 belongs to the GDNF receptor family. It is a glycosyl-phosphatidylinositol (GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor.

Format

Affinity-purified

Clonality

Polyclonal

Isotype

IgY

Applications

IHC, WB

Host Species

Chicken

Immunogen

Recombinant His-tagged human GFRa-4 protein produced using CHO-based cell line. For production of hGFRa-4, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. Protein was purified by Ni-affinity chromatography following gel-filtration from cell culture supernatant.

Immunogen Species

Human

Species Reactivity

Human

Storage

ready to dilute once thawedStore at -80°C upon receipt. Divide antibody into aliquots upon receipt. Avoid multiple freeze-thaw cycles as product degradation may result.

Physical State

Liquid

Buffer

Concentrated ammonium sulphate in PBS pH 7.4 containing no preservatives.

Dilution Ranges

WB: 1:5000-1:10000
ICC: 1:1000-1:3000

Conjugate

Unconjugated

Specificity

Human GFRa-4. This antibody does not cross-react with hGFRa-1, hGFRa-2, hGFRa-3.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

GDNF family receptor alpha-4; GDNF receptor alpha-4; GDNFR-alpha-4; Persephin receptor; GFR receptor alpha 4; GFR-alpha-4

UniProt ID

Q9GZZ7
UniProt Summary: Receptor for persephin (PSPN), a growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.

NCBI Gene ID

64096

Shipping

2-8°C (on cold packs)

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Anti-GDNF family receptor alpha-4 (GFR alpha-4) Antibody

SKU: C-1662-100

Product Details

Bulk Order Anti-GDNF family receptor alpha-4 (GFR alpha-4) Antibody

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