Anti-ETR3 (CUGBP2) Antibody

Name: Anti-ETR3 (CUGBP2) Antibody
Brand: PhosphoSolutions
SKU: 24130
Price: 456.0 USD
Availability: InStock

Our ETR3 (CUGBP2) rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human and mouse ETR3 (CUGBP2) and is antigen affinity purified. It is great for use in WB.

Western Blot of mouse heart lysate showing specific immunolabeling of ETR3/CUGBP2.

Click on image to zoom

Species Reactivity

Human, Mouse

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 24130

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

ETR3 (CUGBP2)

Scientific Background

Cardiac elav-type RNA-binding protein (ETR-3), which binds to RNAs containing CUG repeats in patients with myotonic dystrophy. ETR-3 is involved in regulating RNA processing of cardiac genes.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

CELF2

Immunogen

Synthetic peptide corresponding to amino acids from the C-terminal region of human ETR3 protein

Immunogen Species

Human

Species Reactivity

Human, Mouse

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the C-terminal region of human and mouse ETR-3

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

BRUNOL3; Bruno-like protein 3; CUG-BP2; CUGBP2; ETR-3; ETR3; NAPOR; CUGBP Elav-like family member 2; CUG triplet repeat RNA-binding protein 2; CUG-BP- and ETR-3-like factor 2; ELAV-type RNA-binding protein 3; KDM2B/CELF2 fusion; RNA-binding protein BRUNOL-3; CELF2; Cardiac elav type RNA binding protein; CUG BP2; Neuroplastoma apoptosis related RNA binding protein 3

UniProt ID

O95319
UniProt Summary: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediately upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF1, negatively regulates the processing to mature miRNA.

NCBI Gene ID

10659

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Anti-ETR3 (CUGBP2) Antibody

SKU: 24130

Product Details

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