Anti-Bcl10 Antibody

Name: Anti-Bcl10 Antibody
Brand: PhosphoSolutions
SKU: 24129
Price: 456.0 USD
Availability: InStock

Our Bcl10 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human Bcl10 and is antigen affinity purified. It is great for use in WB.

Western Blot of transfected 293 cell lysate showing specific immunolabeling of Bcl10.

Click on image to zoom

Species Reactivity

Human

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 24129

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Bcl10

Scientific Background

Bcl10 is a novel gene with an amino-terminal caspase-recruiting domain (CARD), which is thought to be involved in mucosa-associated lymphoid tissue lymphomas and in the pathogenesis of several other human malignancies.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

BCL10

Immunogen

Synthetic peptide corresponding to amino acids from the C-terminal region of human Bcl10 protein

Immunogen Species

Human

Species Reactivity

Human

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the C-terminal region of human Bcl10 protein

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

CARMEN; B-cell lymphoma/leukemia 10; CLAP; IMD37; c-E10; mE10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; cCARMEN; caspase-recruiting domain-containing protein; cellular homolog of vCARMEN; cellular-E10; hCLAP; mammalian CARD-containing adapter molecule E10; CARD containing apoptotic signaling protein; B-cell CLL/lymphoma 10; CARD containing molecule enhancing NF kappa B; CARD containing proapoptotic protein; CARD containing molecule enhancing NFkB; Caspase recruiting domain containing protein

UniProt ID

O95999
UniProt Summary: Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation. Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex. This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity. Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK.

NCBI Gene ID

8915

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Anti-Bcl10 Antibody

SKU: 24129

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