Anti-CD28 Antibody

Name: Anti-CD28 Antibody
Brand: PhosphoSolutions
SKU: 24144
Price: 456.0 USD
Availability: InStock

Our CD28 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human CD28 and is antigen affinity purified. It is great for use in WB.

Western Blot of CD4+ cells showing specific immunolabeling of CD28.

Click on image to zoom

Species Reactivity

Human

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 24144

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

CD28

Scientific Background

CD28 is a T-cell-specific cell-surface receptor that is responsible for enhancing T-cell responses during an immune response.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

CD28

Immunogen

Synthetic peptide corresponding to amino acids from the Ig-V-like region human CD28 protein

Immunogen Species

Human

Species Reactivity

Human

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the Ig-V-like region of human CD28 protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

Tp44; T cell specific surface glycoprotein; CD28 antigen

UniProt ID

P10747
UniProt Summary: Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis. Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells. Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets. Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways. In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells.

NCBI Gene ID

940

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Anti-CD28 Antibody

SKU: 24144

Product Details

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