Anti-Alien Antibody

Name: Anti-Alien Antibody
Brand: PhosphoSolutions
SKU: 24139
Price: 456.0 USD
Availability: InStock

Our Alien rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects drosophila, human, mouse, and rat Alien and is antigen affinity purified. It is great for use in WB.

Western Blot of HeLa cell lysate showing specific immunolabeling of Alien (aka COP9 signalosome complex subunit 2).

Click on image to zoom

Species Reactivity

Drosophila, Human, Mouse, Rat

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 24139

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Alien

Scientific Background

Alien (aka COP9 signalosome complex subunit 2) is a novel co-repressor that interacts with the thyroid hormone receptor in the absence of hormone. Alien is highly conserved between human and Drosophila and is specific for selected members of the nuclear hormone receptor superfamily.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

COPS2

Immunogen

Synthetic peptide corresponding to amino acids from an internal region of human Alien protein

Immunogen Species

Human

Species Reactivity

Drosophila, Human, Mouse, Rat

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with an internal region of human Alien protein

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

ALIEN; COP9 signalosome complex subunit 2; SGN2; TRIP15; JAB1-containing signalosome subunit 2; TR-interacting protein 15; TRIP-15; alien homolog; signalosome subunit 2; thyroid receptor-interacting protein 15; CSN2; COPS2; JAB1 containing signalosome subunit 2; Thyroid Hormone Receptor Interactor 15

UniProt ID

P61201
UniProt Summary: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.

NCBI Gene ID

9318

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Anti-Alien Antibody

SKU: 24139

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