Anti-Autophagy-related protein 12 (ATG12) Antibody

Name: Anti-Autophagy-related protein 12 (ATG12) Antibody
Brand: Biosensis
SKU: R-112-100
Price: 337.0 USD
Availability: InStock

Our Anti-Autophagy-related protein 12 (ATG12) rabbit polyclonal primary antibody detects human and rat Autophagy-related protein 12 (ATG12), and is whole serum. It is validated for use in IHC-Frozen, WB.

Confocal microscopy on stained ATG12 using Rabbit antibody to ATG12: whole serum (R-112-100) in paraffin embedded human brian section (midfrontal cortex, Alzheimer case).

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Species Reactivity

Human, Rat

Applications

IHC, WB

Host Species

Rabbit

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Data Sheet

SKU: R-112-100

Volume/Size: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Autophagy-related protein 12 (ATG12)

Scientific Background

FUNCTION: Required for autophagy. SUBUNIT: Conjugated to ATG5. SUBCELLULAR LOCATION: Cytoplasm. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Belongs to the ATG12 family.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

IHC, WB

Host Species

Rabbit

Immunogen

A synthetic peptide corresponding to the N-terminal of human ATG12 protein has been used as the immunogen. No immunogenic carrier protein was conjugated to the immunogen. Instead, Adjukine B (see the Adjuvants in biosensis' product list) has been used to orchestrate/boost the immune response.

Immunogen Species

Human

Species Reactivity

Human, Rat

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Dilution Ranges

WB: 1:200-1:1000
IHC: 1:200-1:1000
ICC: 1:200-1:1000

Conjugate

Unconjugated

Specificity

IHC and WB confirmed the specificity for ATG12. Human, rat.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

APG12; Autophagy-related protein 12; FBR93; APG12-like; HAPG12; APG 12; ubiquitin-like protein ATG12; ATG12; APG12 autophagy 12-like; ATG12 autophagy related 12 homolog; APG12L; Apg12 (autophagy; yeast homolog

UniProt ID

O94817
UniProt Summary: Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. As part of the ATG8 conjugation system with ATG5 and ATG16L1, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress.

NCBI Gene ID

9140

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Anti-Autophagy-related protein 12 (ATG12) Antibody

SKU: R-112-100

Product Details

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