Anti-Thyroid Hormone Receptor Beta1 Antibody FL594 Conjugate (N402/46)

Name: Anti-Thyroid Hormone Receptor Beta1 Antibody FL594 Conjugate
Brand: NeuroMab
SKU: 75-387-FL594
Price: 486.0 USD
Availability: InStock

Our mouse Thyroid hormone receptor beta1 FL594 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N402/46. It detects human, mouse, and rat Thyroid hormone receptor beta1 and is purified by Protein A chromatography. Works in IHC, ICC.

Anti-Thyroid Hormone Receptor Beta1 Antibody FL594 Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-387-FL594

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Thyroid hormone receptor beta1

Scientific Background

Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N402/46

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

THRB ERBA2 NR1A2 THR1

Molecular Weight

60 kDa

Immunogen

Fusion protein amino acids 1-461 (full-length) of human Thyroid hormone receptor beta1 (accession number P10828) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2940278

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL594 Ex: 594 nm, Em: 615 nm

Specificity

Does not cross-react with Thyroid hormone receptor beta2 or alpha1

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)

UniProt ID

P10828

Shipping

Shipped on ice packs

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Anti-Thyroid Hormone Receptor Beta1 Antibody FL594 Conjugate (N402/46)

SKU: 75-387-FL594

Product Details

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