Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)
Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRa1, TRa2, TRß1 and TRß2. TRa1, TRß1 and TRß2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).
ICC, IHC, WB
THRB ERBA2 NR1A2 THR1
Fusion protein amino acids 1-461 (full-length) of human Thyroid hormone receptor beta1 (also known as Nuclear receptor subfamily 1 group A member 2, c-erbA-2, c-erbA-beta, THRB, ERBA2, NR1A2 and THR1, accession number P10828); Mouse: 96% identity (445/461 amino acids identical); Rat: 95% identity (442/461 amino acids identical); 75% identity with Thyroid hormone receptor beta; 280% identity with Thyroid hormone receptor alpha1
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.