Anti-Kv3.3 Potassium Channel Antibody FL594 Conjugate (N375/67)

Name: Anti-Kv3.3 Potassium Channel Antibody FL594 Conjugate
Brand: NeuroMab
SKU: 75-354-FL594
Price: 486.0 USD
Availability: InStock

Our mouse Kv3.3 potassium channel FL594 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N375/67. It detects human, mouse, and rat Kv3.3 potassium channel and is purified by Protein A chromatography. Works in IHC, ICC.

Anti-Kv3.3 Potassium Channel Antibody FL594 Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-354-FL594

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Kv3.3 potassium channel

Scientific Background

Potassium voltage-gated channel subfamily C member 3 or Kv3.3 potassium channel, is a member of the potassium channel, voltage-gated, shaker-related subfamily and the Shaw subfamily (the family includes 4 members Kv3.1-Kv3.4). Note that this protein has several splice variants and that antibody N375/67 recognizes both Kv3.3b and Kv3.3a. Kv3.3 is primarily expressed in brain. Kv3.3 is highly expressed in purkinje cells and deep cerebellar nuclei in the cerebellum. Kv3.3a is also expressed in brain, but not found in the cerebellum. Kv3.3 is a membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Diseases associated with the gene for this protein (Kcnc3) include Spinocerebellar Ataxia 13 and Autosomal recessive ataxic cerebral palsy.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N375/67

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Kcnc3

Molecular Weight

80-100 kDa (depending on isoform)

Immunogen

Fusion protein amino acids 628-728 (cytoplasmic C-terminus) of mouse Kv3.3b (accession number Q63959) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2940190

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL594 Ex: 594 nm, Em: 615 nm

Specificity

Does not cross-react with Kv3.4 or Kv3.2

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Potassium voltage-gated channel subfamily C member 3 (KSHIIID) (Voltage-gated potassium channel subunit Kv3.3)

UniProt ID

Q63959

Shipping

Shipped on ice packs

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Anti-Kv3.3 Potassium Channel Antibody FL594 Conjugate (N375/67)

SKU: 75-354-FL594

Product Details

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