Potassium voltage-gated channel subfamily C member 3 or Kv3.3 potassium channel, is a member of the potassium channel, voltage-gated, shaker-related subfamily and the Shaw subfamily (the family includes 4 members Kv3.1-Kv3.4). Note that this protein has several splice variants and that antibody N375/67 recognizes both Kv3.3b and Kv3.3a. Kv3.3 is primarily expressed in brain. Kv3.3 is highly expressed in purkinje cells and deep cerebellar nuclei in the cerebellum. Kv3.3a is also expressed in brain, but not found in the cerebellum. Kv3.3 is a membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Diseases associated with the gene for this protein (Kcnc3) include Spinocerebellar Ataxia 13 and Autosomal recessive ataxic cerebral palsy.
Purified by Protein A chromatography
ICC, IHC, WB
80-100 kDa (depending on isoform)
Fusion protein amino acids 628-728 (cytoplasmic C-terminus) of mouse Kv3.3b (accession number Q63959) produced recombinantly in E. Coli
Human, Mouse, Rat
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Does not cross-react with Kv3.4 or Kv3.2
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from date of receipt
Shipped on ice packs
Potassium voltage-gated channel subfamily C member 3 (KSHIIID) (Voltage-gated potassium channel subunit Kv3.3)