Potassium voltage-gated channel subfamily C member 3 (KSHIIID) (Voltage-gated potassium channel subunit Kv3.3)
Potassium voltage-gated channel subfamily C member 3 or Kv3.3 potassium channel, is a member of the potassium channel, voltage-gated, shaker-related subfamily and the Shaw subfamily (the family includes 4 members Kv3.1-Kv3.4). Note that this protein has several splice variants and that antibody N375/67 recognizes both Kv3.3b and Kv3.3a. Kv3.3 is primarily expressed in brain. Kv3.3 is highly expressed in purkinje cells and deep cerebellar nuclei in the cerebellum. Kv3.3a is also expressed in brain, but not found in the cerebellum. Kv3.3 is a membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Diseases associated with the gene for this protein (Kcnc3) include Spinocerebellar Ataxia 13 and Autosomal recessive ataxic cerebral palsy.
ICC, IHC, WB
80-100 kDa (depending on isoform)
Fusion protein amino acids 628-728 (cytoplasmic C-terminus) of mouse Kv3.3b (also known as Potassium voltage-gated channel subfamily C member 3, KSHIIID and Kcnc3, accession number Q63959); Human: 96% identity (94/97 amino acids identical); Rat: 90% identity (96/106 amino acids identical); 100% identity with Kv3.3a for first 30 amino acids (AGGLGIMGLPPLPAPGEPCPLEEVIETNRA); Less than 40% identity with Kv3.4 or Kv3.2
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.