Anti-Kv3.3 Potassium Channel Antibody (N375/67)

Name: Anti-Kv3.3 Potassium Channel Antibody
Brand: NeuroMab
SKU: 75-354
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnc3

Molecular Weight

80-100 kDa (depending on isoform)

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Adult rat hippocampus immunohistochemistry.

$Immunoblot against adult rat brain membrane (RBM) fractions and extracts of COS cells transiently transfected with untagged Kv3.3a, Kv3.3b or Kv2.1 plasmid probed with N375/67 (left) or N52A/42 (right) TC supe.$

Adult rat hippocampus immunohistochemistry.

Product Details

Target

Potassium voltage-gated channel subfamily C member 3 (KSHIIID) (Voltage-gated potassium channel subunit Kv3.3)

Target Description

Potassium voltage-gated channel subfamily C member 3 or Kv3.3 potassium channel, is a member of the potassium channel, voltage-gated, shaker-related subfamily and the Shaw subfamily (the family includes 4 members Kv3.1-Kv3.4). Note that this protein has several splice variants and that antibody N375/67 recognizes both Kv3.3b and Kv3.3a. Kv3.3 is primarily expressed in brain. Kv3.3 is highly expressed in purkinje cells and deep cerebellar nuclei in the cerebellum. Kv3.3a is also expressed in brain, but not found in the cerebellum. Kv3.3 is a membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Diseases associated with the gene for this protein (Kcnc3) include Spinocerebellar Ataxia 13 and Autosomal recessive ataxic cerebral palsy.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N375/67

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnc3

Molecular Weight

80-100 kDa (depending on isoform)

Antigen

Fusion protein amino acids 628-728 (cytoplasmic C-terminus) of mouse Kv3.3b (also known as Potassium voltage-gated channel subfamily C member 3, KSHIIID and Kcnc3, accession number Q63959); Human: 96% identity (94/97 amino acids identical); Rat: 90% identity (96/106 amino acids identical); 100% identity with Kv3.3a for first 30 amino acids (AGGLGIMGLPPLPAPGEPCPLEEVIETNRA); Less than 40% identity with Kv3.4 or Kv3.2

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2315872

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with Kv3.4 or Kv3.2

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Potassium voltage-gated channel subfamily C member 3 (KSHIIID) (Voltage-gated potassium channel subunit Kv3.3)

UniProt Details

UniProt (Human): O14649
UniProt (Immunogen Species): Q63959

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Anti-Kv3.3 Potassium Channel Antibody (N375/67)

Anti-Kv3.3 Potassium Channel Antibody
SKU: 75-354

Product Details

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Anti-Kv3.3 Potassium Channel Antibody (N375/67)

Anti-Kv3.3 Potassium Channel Antibody SKU: 75-354

Product Details

Anti-Kv3.3 Potassium Channel Antibody
SKU: 75-354