Anti-GABA-A-R-Alpha5 Antibody FL550 Conjugate (N415/24)

Name: Anti-GABA-A-R-Alpha5 Antibody FL550 Conjugate
Brand: NeuroMab
SKU: 75-401-FL550
Price: 486.0 USD
Availability: InStock

Our mouse GABA-A-R-Alpha5 FL550 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N415/24. It detects human, mouse, and rat GABA-A-R-Alpha5 and is purified by Protein A chromatography. KO validated. Works in IHC, ICC.

Anti-GABA-A-R-Alpha5 Antibody FL550 Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

594

650

Biotin

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-401-FL550

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

GABA-A-R-Alpha5

Scientific Background

Gamma-Aminobutyric Acid Type A Receptor Alpha5 Subunit or GABA(A) Receptor, Alpha 5 is encoded by the gene GABRA5. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR alpha 5 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR alpha5 is highly expressed in brain at the cell junction, synapse, postsynaptic cell membrane and cytoplasmic vesicle membrane. Disorders involving the GABRA5 gene include Angelman Syndrome, Prader-willi syndrome and childhood absence epilepsy.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N415/24

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

GABRA5

Molecular Weight

55 kDa

Immunogen

Fusion protein amino acids 368-419 (last cytoplasmic domain before extracellular C-terminus) of human GABA-A-R-Alpha5 (accession number P31644) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2940321

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL550 Ex: 550 nm, Em: 575 nm

Specificity

Does not cross-react with GABA-A-R-Alpha2 (or other GABAA

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5)

UniProt ID

P31644

Shipping

Shipped on ice packs

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Anti-GABA-A-R-Alpha5 Antibody FL550 Conjugate (N415/24)

SKU: 75-401-FL550

Product Details

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