Anti-GABA-A-R-Alpha5 Antibody (N415/24)

Name: Anti-GABA-A-R-Alpha5 Antibody
Brand: NeuroMab
SKU: 75-401
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

Product Type

Primary Antibody

Species Reactivity

Human, Mouse

Clone

N415/24

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

GABRA5

Molecular Weight

55 kDa

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$Immunoblot against crude low-speed pellet fractions from adult rat brain (RBLSP) and wild-type (WT) and GABA-A-R- Alpha5 knockout (KO) mouse brains probed with N415/24 (left) and N52A/42 (right) TC supe. Mouse brains courtesy of Uwe Rudolph (Harvard Medical School).$

Immunoblot against crude low-speed pellet fractions from adult rat brain (RBLSP) and wild-type (WT) and GABA-A-R- Alpha5 knockout (KO) mouse brains probed with N415/24 (left) and N52A/42 (right) TC supe. Mouse brains courtesy of Uwe Rudolph (Harvard Medical School).

Volume: 100 µL

Variant

Price:

$295

Quantity:

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Product Details

Target

Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5)

Target Description

Gamma-Aminobutyric Acid Type A Receptor Alpha5 Subunit or GABA(A) Receptor, Alpha 5 is encoded by the gene GABRA5. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR alpha 5 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR alpha5 is highly expressed in brain at the cell junction, synapse, postsynaptic cell membrane and cytoplasmic vesicle membrane. Disorders involving the GABRA5 gene include Angelman Syndrome, Prader-willi syndrome and childhood absence epilepsy.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N415/24

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

GABRA5

Molecular Weight

55 kDa

Antigen

Fusion protein amino acids 368-419 (last cytoplasmic domain before extracellular C-terminus) of human GABA-A-R-Alpha5 (also known as Gamma-aminobutyric acid receptor subunit alpha-5, GABA(A) receptor subunit alpha-5 and Gabra5, accession number P31644); Mouse: 78% identity (41/52 amino acids identical); Rat: 73% identity (39/53 amino acids identical); 50% identity with GABA-A-R-Alpha2 and other GABA-A receptors

Species Reactivity

Human, Mouse

Antibody Registry ID

AB_2491187

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with GABA-A-R-Alpha2 (or other GABAA

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5)

UniProt Details

UniProt (Human): P31644
UniProt (Immunogen Species): P31644

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Anti-GABA-A-R-Alpha5 Antibody (N415/24)

Anti-GABA-A-R-Alpha5 Antibody
SKU: 75-401

Bulk Order Anti-GABA-A-R-Alpha5 Antibody

Product Details

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Anti-GABA-A-R-Alpha5 Antibody (N415/24)

Anti-GABA-A-R-Alpha5 Antibody SKU: 75-401

Bulk Order Anti-GABA-A-R-Alpha5 Antibody

Product Details

Anti-GABA-A-R-Alpha5 Antibody
SKU: 75-401