Anti-CALB1/calbindin Recombinant Chicken Chimeric mAb FL594 Conjugate (L109/57)

Name: Anti-CALB1/calbindin Recombinant Chicken Chimeric mAb FL594 Conjugate
Brand: Aves Labs
SKU: 78-448-FL594
Price: 549.0 USD
Availability: InStock

Our chicken Anti-CALB1/calbindin recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone L109/57. It detects human, mouse, and rat CALB1/calbindin, and is purified by affinity chromatography. It is great for use in AT, ICC, IHC, WB.

Anti-CALB1/calbindin Recombinant Chicken Chimeric mAb FL594 Conjugate

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Applications

ICC, IHC

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

650

Carrier-Free

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Data Sheet

SKU: 78-448-FL594

Volume: 200 µL

Variant

Price:

$549.00

Quantity:

Ships: 1-5 business days

Product Details

Target

CALB1/calbindin

Scientific Background

Calbindin (aka. calbindin D28k) is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. It is predominantly expressed in certain types of neurons, particularly in dendrites and perikarya of the cerebellum and is thought to buffer entry of calcium upon stimulation of glutamate receptors (Andressen et al., 1993). Calbindin has recently been shown to play a critical role in mitochondrial dysfunction and loss of synaptic proteins in vivo in an Alzheimer’s disease mouse model (Kook et al., 2014).

Format

Purified by affinity chromatography

Concentration

0.5 mg/mL

Clonality

Recombinant

Clone

L109/57

Isotype

IgY

Applications

ICC, IHC

Host Species

Chicken

Gene Name

CALB1 CAB27

Molecular Weight

30 kDa

Excitation / Emission

FL594 Ex: 594 nm, Em: 615 nm

Immunogen

Fusion protein amino acids 1-261 (full-length) of human CALB1 (accession number P05937) produced recombinantly in E. Coli

Immunogen Species

Human

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of our NeuroMab clone L109/57 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone L109/57 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Conjugate

594

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Calbindin (Calbindin D28) (D-28K) (Vitamin D-dependent calcium-binding protein, avian-type)

UniProt ID

P05937

Shipping

Shipped on ice packs

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Anti-CALB1/calbindin Recombinant Chicken Chimeric mAb FL594 Conjugate (L109/57)

SKU: 78-448-FL594

Product Details

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