Anti-TRESK Antibody (N467/1)

Name: Anti-TRESK Antibody
Brand: NeuroMab
SKU: 75-475
Price: 337.0 USD
Availability: InStock

Our mouse TRESK monoclonal antibody from NeuroMab is produced in-house from clone N467/1. It detects mouse and rat TRESK and is purified by Protein A chromatography. Works in WB, ICC, ELISA.

Adult rat brain membrane immunoblot.

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Species Reactivity

Mouse, Rat

Applications

ELISA, ICC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-475

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

TRESK

Scientific Background

Potassium two pore domain channel subfamily K member 18 is encoded by the gene KCNK18. KCNK18 is a member of the two pore domain potassium channel (TC 1.A.1.8) family. KCNK18 is an outward rectifying potassium channel that produces rapidly activating outward rectifier K+ currents. KCNK18 is expressed in the brain, spinal cord, and testis. Diseases associated with KCNK18 include Migraine With or Without Aura 13 and Migraine with Aura.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N467/1

Isotype

IgG2b

Applications

ELISA, ICC, WB

Host Species

Mouse

Gene Name

Kcnk18 Tresk-2 Tresk2

Molecular Weight

40-50 kDa

Immunogen

Fusion protein amino acids 185-283 (intracellular loop) of mouse TRESK (accession number Q6VV64) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2744558

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Gm781; TRESK; Tresk-2; Potassium channel subfamily K member 18; Trik; TWIK-related individual potassium channel; TWIK-related spinal cord potassium channel; 2P K ion channel TRESK; Two-pore-domain potassium channel TRESK; TWIK-related individual K+ channel; Kcnk180; TWIK-related spinal cord K+ channel; Tresk2

UniProt ID

Q6VV64
UniProt Summary: K(+) channel that conducts outward and inward rectifying currents at depolarized and hyperpolarized membrane potentials, respectively. The outward rectifying currents are voltage-dependent, coupled to K(+) electrochemical gradient across the membrane, whereas the inward currents can be induced in response to activation of Ca(2+)-mobilizing receptors. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. In trigeminal ganglia sensory neurons, the heterodimers of KCNK18/TRESK and KCNK2/TREK-1 or KCNK10/TREK-2 inhibit neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency. In thymocytes, conducts K(+) currents upon T cell receptor (TCR) signaling leading to sustained Ca(2+) influx and NF-kappa-B activation, FOXP3 transcription and positive selection of regulatory T cell (Treg) progenitor subsets. Appears to mediate the analgesics effects of hydroxy-alpha-sanshool, a metabolite naturally present in Schezuan pepper and other Xanthoxylum plants.

NCBI Gene ID

332396

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Anti-TRESK Antibody (N467/1)

SKU: 75-475

Product Details

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