Anti-Tau Antibody

Name: Anti-Tau Antibody
Brand: PhosphoSolutions
SKU: 1998-TAU
Price: 456.0 USD
Availability: InStock

Our Anti-Tau primary antibody from PhosphoSolutions is chicken polyclonal. It detects bovine, human, mouse, pig, and rat Tau and is total IgY fraction. It is great for use in WB, IHC, ICC.

Western blot of rat cortical lysate showing specific immunolabeling of the ~48 kDa, ~65 kDa & ~75 kDa tau isoforms.

Immunostaining of cultured E20 rat cortical neurons and glia stained with anti-TAU antibody (Cat. 1998-TAU, green, 1:2000) and anti-MAP2 (red). The blue is DAPI staining nuclear DNA. Anti-TAU labels perikarya, dendrites, axons of neurons while anti-MAP2 only labels dendrites and perikarya of neurons. Where they overlap they appear orange-yellow.

Immunostaining of cultured rat hippocampal neurons stained with anti-TAU antibody (Cat. 1998-TAU, red, 1:1000) along the neuronal processes.

Day 14 (D14) RGC-iNs stained with a DAPI, TAU (Cat. 1998-TAU, 1:1000), and MAP2. Image from publication CC-BY-4.0. PMID: 37773257

Western blot of rat cortical lysate showing specific immunolabeling of the ~48 kDa, ~65 kDa & ~75 kDa tau isoforms.

Click on image to zoom

Species Reactivity

Human, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

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Data Sheet

Trial Size

SKU: 1998-TAU

Volume: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Tau

Scientific Background

Tau is a key microtubule-associated protein that plays an important role in the formation of microtubules in axons (Binder et al. 1985). Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing (Goedert 1990). Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer’s disease (AD), Pick’s disease and progressive supranuclear palsy.

Format

Total IgY fraction

Clonality

Polyclonal

Isotype

IgY

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Gene Name

MAPT

Immunogen

Recombinant full length human tau expressed in and purified from E.Coli.

Immunogen Species

Human

Species Reactivity

Human, Rat

Antibody Registry ID

AB_2492256

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Production Notes

Total IgY fraction.

Buffer

PBS + 10 mM NaN3.

Dilution Ranges

WB: 1:10000
WB Brain: 1:10000
IHC: 1:1000
ICC: 1:1000-1:2000

Conjugate

Unconjugated

Specificity

Specific for the ~48, 65 & 75 kDa tau isoforms.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

AI413597; AW045860; DDPAC; FLJ31424; FTDP 17; G protein beta1/gamma2 subunit interacting factor 1; MAPT; MAPTL; MGC134287; MGC138549; MGC156663; Microtubule associated protein tau; Microtubule associated protein tau isoform 4; Microtubule-associated protein tau; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; Paired helical filament tau; Paired helical filament-tau; PHF tau; PHF-tau; PPND; PPP1R103; Protein phosphatase 1 regulatory subunit 103; pTau; RNPTAU; TAU; TAU_HUMAN; Tauopathy and respiratory failure included

UniProt ID

P10636
UniProt Summary: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. {ECO:0000269|PubMed:21985311, ECO:0000269|PubMed:32961270}.

NCBI Gene ID

4137

Shipping

Blue Ice

Tau Cultured Rat Hippocampal Neurons ICC Protocol: Download

Tau Cultured E20 Rat Cortical Neuron/Glia Cultures ICC Protocol: Download

Western Blot Protocol: Download

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Anti-Tau Antibody

SKU: 1998-TAU

Product Details

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