Anti-Rufy3 Antibody (N483/126)

Name: Anti-Rufy3 Antibody
Brand: NeuroMab
SKU: 75-500
Price: 337.0 USD
Availability: InStock

Our mouse Rufy3 monoclonal antibody from NeuroMab is produced in-house from clone N483/126. It detects human, mouse, and rat Rufy3 and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Adult rat hippocampus (top) and thalamus (bottom) immunohistochemistry

Adult rat hippocampus (top) and thalamus (bottom) immunohistochemistry

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-500

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Rufy3

Scientific Background

Rufy3 (RUN And FYVE Domain Containing 3) or rap2 interacting protein x,single axon-related 1 (RIPX) contains a RUN domain and two coiled-coil domains. It is implicated in the formation of a single axon by developing neurons and is thought to play a role in the generation of neuronal polarity formation and axon growth. Diseases associated with RUFY3 include Gastric Cancer

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N483/126

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Rufy3

Molecular Weight

55 kDa

Immunogen

Fusion protein amino acids 370-469 (C-terminus) of mouse Rufy3 (accession number Q9D394) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2744557

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

2810428M05Rik; RUN and FYVE domain-containing protein 3; AW455998; AW538594; D5Bwg0860e; Rpipx; singar; singar1; single axon-regulated protein 1; Rap2-interacting protein x; Single axon-regulated protein; KIAA0871; D5Bwg0860e and Ripx

UniProt ID

Q9D394
UniProt Summary: ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma. Plays a role in the generation of neuronal polarity formation and axon growth. Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes. Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery. Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones.

NCBI Gene ID

52822

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Anti-Rufy3 Antibody (N483/126)

SKU: 75-500

Product Details

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