Anti-Parvalbumin Recombinant Chicken Chimeric mAb FL594 Conjugate (L114/81)

Name: Anti-Parvalbumin Recombinant Chicken Chimeric mAb FL594 Conjugate
Brand: Aves Labs
SKU: 78-479-FL594
Price: 562.0 USD
Availability: InStock

Our chicken Anti-Parvalbumin FL594 conjugate recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone L114/81. It detects mouse and rat Parvalbumin and is purified by affinity chromatography. Works in ICC, IHC.

Anti-Parvalbumin Recombinant Chicken Chimeric mAb FL594 Conjugate

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Applications

ICC, IHC

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

650

Biotin

Carrier-Free

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Data Sheet

SKU: 78-479-FL594

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Parvalbumin

Scientific Background

Parvalbumin (PA) is a classical small, mostly cytosolic Ca2+-binding protein of the EF-hand superfamily expressed in vertebrates in a tissue- and cell-specific manner, serving as a magnesium/ calcium buffer (Permyakov EA et al., 2017). Parvalbumin (PV)-expressing interneurons are a class of inhibitory neurons that fire rapid barrages of action potentials, and are accordingly named “fast-spiking” interneurons (Trachtenberg J. 2015).

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

L114/81

Isotype

IgY

Applications

ICC, IHC

Host Species

Chicken

Gene Name

Pvalb Pva

Molecular Weight

12 kDa

Excitation / Emission

FL594 Ex: 594 nm, Em: 615 nm

Immunogen

Fusion protein amino acids 1-110 (full-length) of rat Parvalbumin (accession number P02625) produced recombinantly in E. Coli

Immunogen Species

Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of our NeuroMab clone L114/81 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone L114/81 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Conjugate

594

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

bA122O1.1; Parvalbumin alpha; GABA and glycine transporter; hVIAAT; SLC32A1; SLC32A 1; solute carrier family 32 (GABA vesicular transporter member 1; Solute carrier family 32 member 1; Vesicular GABA Amino Acid Transporter; Vesicular GABA transporter; Vesicular inhibitory amino acid transporter; VGAT; VIAAT; VIAAT_HUMAN

UniProt ID

Q9H598
UniProt Summary: Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient. May also transport beta-alanine. Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake.

NCBI Gene ID

140679

Shipping

Shipped on ice packs

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Anti-Parvalbumin Recombinant Chicken Chimeric mAb FL594 Conjugate (L114/81)

SKU: 78-479-FL594

Product Details

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