Anti-Pan-Kvbeta Potassium Channel Antibody (K25/73)

Name: Anti-Pan-Kvbeta Potassium Channel Antibody
Brand: NeuroMab
SKU: 75-392
Price: 337.0 USD
Availability: InStock

Our mouse Pan-Kvbeta potassium channel monoclonal antibody from NeuroMab is produced in-house from clone K25/73. It detects human, mouse, and rat Pan-Kvbeta potassium channel and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Adult rat brain membrane immunoblot

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-392

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Pan-Kvbeta potassium channel

Scientific Background

The ß subunits of voltage-gated potassium channels are members of the potassium channel, voltage-gated, shaker-related subfamily. Kvβs are cytoplasmic subunits that modulate the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on other channel proteins. There are three ß subunits (Kvß1, Kvß2, Kvß3) which are coded by three different genes. Additionally, there is alternative splicing of these three genes, further diversifying the functions and tissue expression of the family.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K25/73

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnab1 Kvb1 Kcnab3 Ckbeta3 Kcnab2 Ckbeta2 Kcnb3

Molecular Weight

40 kDa

Immunogen

Synthetic peptide amino acids 350-367 (EIDSILGNKPYSKKDYRS, C-terminus) of human Kvbeta2 (accession number Q13303)

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2491089

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Reacts with Kvbeta1

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

AKR6A5; Voltage-gated potassium channel subunit beta-1; HKvbeta2.1; EC 1.1.1.-; HKvbeta2.2; K(+ channel subunit beta-1; KCNA2B; Kv-beta-1 Voltage-gated potassium channel subunit beta-3; K(+ channel subunit beta-2; K(+ channel subunit beta-3; KV-BETA-2; Kv-beta-3; voltage-gated potassium channel subunit beta-2; RCK beta3 Voltage-gated potassium channel subunit beta-2

UniProt ID

Q13303
UniProt Summary: Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels. Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates. Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet). The binding of oxidized and reduced nucleotide alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability. Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability.

NCBI Gene ID

8514

Shipping

Shipped on ice packs

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Anti-Pan-Kvbeta Potassium Channel Antibody (K25/73)

SKU: 75-392

Product Details

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