Anti-Pan-FHF-A Antibody (N235/22)

Name: Anti-Pan-FHF-A Antibody
Brand: NeuroMab
SKU: 75-246
Price: 337.0 USD
Availability: InStock

Our mouse Pan-FHF-A monoclonal antibody from NeuroMab is produced in-house from clone N235/22. It detects human, mouse, and rat Pan-FHF-A and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Adult rat hippocampus immunohistochemistry.

Adult rat hippocampus immunohistochemistry.

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-246

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Pan-FHF-A

Scientific Background

FGF12A/FHF1A and FGF14A/FHF4A are members of the fibroblast growth factor homologous factors family (a subfamily of fibroblast growth factors.). FHFs have a role in regulation of voltage gated sodium channels (Nav channels) and are thought to be involved in nervous system development.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N235/22

Isotype

IgG2b

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

FGF13 FHF2

Molecular Weight

30 kDa

Immunogen

Synthetic peptide amino acids 2-18 (AAAIASSLIRQKRQARE) of human FHF2A (accession number Q92913)

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_10697884

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Dilution Ranges

WB: 1:1000
ICC: 1:500

Conjugate

Unconjugated

Specificity

Cross-reacts with FGF12A/FHF1A and FGF14A/FHF4ADoes not cross-react with FGF13B/FHF2B

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

FGF-13; cross reacts with FGF12A/FHF1A and FGF14A/FHF4A; FHF-2; FHF2; fibroblast growth factor 13; fibroblast growth factor homologous factor 2

UniProt ID

Q92913
UniProt Summary: Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. Regulates voltage-gated sodium channel transport and function. May also play a role in MAPK signaling. Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons.

NCBI Gene ID

2258

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Shipped on ice packs

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Anti-Pan-FHF-A Antibody (N235/22)

SKU: 75-246

Product Details

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