Anti-Malin Antibody (N85/18)

Name: Anti-Malin Antibody
Brand: NeuroMab
SKU: 75-128
Price: 337.0 USD
Availability: InStock

Our mouse Malin monoclonal antibody from NeuroMab is produced in-house from clone N85/18. It detects human, mouse, non-human primate, and rat Malin and is purified by Protein A chromatography. Works in WB, ICC, ELISA.

Immunoblot against extracts of COS cells transiently transfected with Flag-tagged Malin or untagged Kv2.1 plasmid probed with N85/18 TC supe (left) or rabbit polyclonal (right).

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Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Applications

ELISA, ICC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-128

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Malin

Scientific Background

NHL Repeat Containing E3 Ubiquitin Protein Ligase 1 is encoded by the gene NHLRC1. NHLRC1 is an E3 ubiquitin-protein ligase which is involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. NHLRC1 is expressed in the brain, spinal cord, heart, liver, skeletal muscle, and pancreas. Diseases associated with NHLRC1 include Myoclonic Epilepsy of Lafora and Epilepsy.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N85/18

Isotype

IgG1

Applications

ELISA, ICC, WB

Host Species

Mouse

Gene Name

NHLRC1 EPM2B

Molecular Weight

42 kDa

Immunogen

Fusion protein amino acids 2-125 (N-terminus encompassing RING domain) of human Malin (also known as NHL repeat-containing protein 1, E3 ubiquitin-protein ligase NHLRC1, NHLRC1 and EPM2B, accession number Q6VVB1)

Immunogen Species

Human

Species Reactivity

Human, Mouse, Non-Human Primate, Rat

Antibody Registry ID

AB_2153100

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.55

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

EPM2A; E3 ubiquitin-protein ligase NHLRC1; MALIN; EC 2.3.2.27; bA204B7.2; NHL repeat-containing protein 1; NHL repeat containing 1; RING-type E3 ubiquitin transferase NHLRC1

UniProt ID

Q6VVB1
UniProt Summary: E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.

NCBI Gene ID

378884

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Anti-Malin Antibody (N85/18)

SKU: 75-128

Product Details

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