Anti-Lipid phosphate phosphohydrolase 3 (LPP3) Antibody (7H7D3)

Name: Anti-Lipid phosphate phosphohydrolase 3 (LPP3) Antibody
Brand: Biosensis
SKU: M-1560-100
Price: 347.0 USD
Availability: InStock

Our Anti-Lipid phosphate phosphohydrolase 3 (LPP3) mouse monoclonal primary antibody detects human Lipid phosphate phosphohydrolase 3 (LPP3), and is affinity-purified. It is validated for use in FC, WB.

Anti-Lipid phosphate phosphohydrolase 3 (LPP3) Antibody

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Species Reactivity

Human

Applications

Flow, WB

Host Species

Mouse

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Data Sheet

SKU: M-1560-100

Volume/Size: 100 µg

Variant

Price:

$347.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Lipid phosphate phosphohydrolase 3 (LPP3)

Scientific Background

Lipid phosphate phosphohydrolase 3 (LPP3) is a member of the phosphatidic acid phosphatase (PAP) family. LPP3 catalyzes the conversion of phosphatidic acid to diacylglycerol. In addition it hydrolyzes lysophosphatidic acid, ceramide-1-phosphate and sphingosine-1-phosphate (Ref: SWISSPROT).

Format

Affinity-purified

Clonality

Monoclonal

Clone

7H7D3

Isotype

Mixed

Applications

Flow, WB

Host Species

Mouse

Immunogen

A synthetic peptide from human LPP3 (179-196 aa) conjugated to KLH.

Immunogen Species

Human

Species Reactivity

Human

Storage

Spin vial briefly before opening. Reconstitute in 100 uL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. At least 12 months after purchase at 2-8°C (lyophilized formulations). After reconstitution, aliquot and store at -20°C for a higher stability and at 2-8°C with an appropriate antibacterial agent. Avoid freeze-thaw cycles.

Physical State

Lyophilized

Production Notes

Affinity purified

Buffer

Lyophilized from PBS pH 7.4

Dilution Ranges

WB: 2-3 µg/mL
IHC: 0.5-2 µg/mL

Application Details

For IHC, this antibody has been shown to work on formalin-fixed, paraffin-embedded tissue samples with heat-induced antigen retrieval. For FACS, the recommended concentration is 2.0 µg/mL.

Conjugate

Unconjugated

Specificity

Confirmed by over-expression of human LPP3 cDNA. Human.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Dri42; Lipid phosphate phosphohydrolase 3; PAP2B; PAP2-beta; PPAP2B; Phosphatidate phosphohydrolase type 2b; VCIP; Phosphatidic acid phosphatase 2b; phospholipid phosphatase 3; PAP-2b; PAP2 beta; Vascular endothelial growth factor and type I collagen-inducible protein; phosphatidic acid phosphatase type 2B; type-2 phosphatidic acid phosphatase-beta; LPP3

UniProt ID

O14495
UniProt Summary: Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes. Through the dephosphorylation of extracellular sphingosine-1-phosphate and the regulation of its extra- and intracellular availability, plays a role in vascular homeostasis, regulating endothelial cell migration, adhesion, survival, proliferation and the production of pro-inflammatory cytokines. By maintaining the appropriate levels of this lipid in the cerebellum, also ensure its proper development and function. Through its intracellular lipid phosphatase activity may act in early compartments of the secretory pathway, regulating the formation of Golgi to endoplasmic reticulum retrograde transport carriers.

NCBI Gene ID

8613

Shipping

25°C (ambient)

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Anti-Lipid phosphate phosphohydrolase 3 (LPP3) Antibody (7H7D3)

SKU: M-1560-100

Product Details

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