Anti-Kv1.6 K+ Channel Antibody FL650 Conjugate (K19/36)

Name: Anti-Kv1.6 K+ Channel Antibody FL650 Conjugate
Brand: NeuroMab
SKU: 75-012-FL650
Price: 486.0 USD
Availability: InStock

Our mouse Kv1.6 K+ channel FL650 conjugate monoclonal antibody from NeuroMab is produced in-house from clone K19/36. It detects human, mouse, and rat Kv1.6 K+ channel and is purified by Protein A chromatography. Works in IHC, ICC.

Anti-Kv1.6 K+ Channel Antibody FL650 Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

Biotin

Carrier-Free

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Data Sheet

SKU: 75-012-FL650

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Kv1.6 K+ channel

Scientific Background

Potassium voltage-gated channel subfamily A member 6 or Kv1.6 is encoded by the gene KCNA6. Kv1.6 is a potassium channel subunit is a member of the potassium channel, voltage-gated, shaker-related subfamily. Potassium channels form homotetrameric and heterotetrameric channels in the membrane with various other related proteins, including KCNA2, KCNA4, KCNA5, KCNA6, KCNA7. Kv1.6 is expressed in brain neurons as well as other cell types in the brain, in cardiac and smooth muscle tissue, ovary and testis.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

K19/36

Isotype

IgG3

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Kcna6

Molecular Weight

60 kDa

Immunogen

Synthetic peptide 507-525 (RERRSSYLPTPHRAYAEKR; cytoplasmic C-terminus) of rat Kv1.6 (accession number P17659)

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939111

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

Specificity

Does not cross-react with other Kv1 channels

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

HBK2; Potassium voltage-gated channel subfamily A member 6; PPP1R96; RCK2; human brain potassium channel-2; Voltage-gated potassium channel subunit Kv1.6; protein phosphatase 1; Voltage-gated potassium channel subunit Kv2; regulatory subunit 96; voltage-gated potassium channel HBK2; voltage-gated potassium channel protein Kv1.6

UniProt ID

P17659
UniProt Summary: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KNCA5, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (Probable). Homotetrameric channels display rapid activation and slow inactivation.

NCBI Gene ID

3742

Shipping

Shipped on ice packs

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Anti-Kv1.6 K+ Channel Antibody FL650 Conjugate (K19/36)

SKU: 75-012-FL650

Product Details

Bulk Order Anti-Kv1.6 K+ Channel Antibody FL650 Conjugate

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