Anti-Kirrel3 Short Isoform 3 Antibody (N320/48)

Name: Anti-Kirrel3 Short Isoform 3 Antibody
Brand: NeuroMab
SKU: 75-282
Price: 337.0 USD
Availability: InStock

Our mouse Kirrel3 short isoform 3 monoclonal antibody from NeuroMab is produced in-house from clone N320/48. It detects mouse and rat Kirrel3 short isoform 3 and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Adult rat hippocampus immunohistochemistry (with antigen retrieval via sodium citrate pretreatment).

Transfected cell immunoblot: extracts of COS cells transiently transfected with Flag-tagged Kirrel3-short, Kirrel3-long or untagged Kv2.1 plasmids and probed with N320/48 (left) and Mouse anti-Flag (right).

Adult rat hippocampus immunohistochemistry (with antigen retrieval via sodium citrate pretreatment).

Click on image to zoom

Species Reactivity

Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-282

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Kirrel3 short isoform 3

Scientific Background

Kirre Like Nephrin Family Adhesion Molecule 3 is encoded by the gene KIRREL3. KIRREL3 is a member of the immunoglobulin superfamily, nephrin-like protein family. KIRREL3 is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. KIRREL3 is expressed in brain, bone marrow, and stromal cells. Diseases associated with KIRREL3 include Autosomal Dominant Non-Syndromic Intellectual Disability and Autosomal Dominant Non-Syndromic Intellectual Disability 4.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N320/48

Isotype

IgG2a

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Kirrel3 Kiaa1867 Neph2

Molecular Weight

70 kDa

Immunogen

Synthetic peptide amino acids 591-608 (VRAQPMPHSILSTQTSRC) of mouse Kirrel3 short isoform 3 (accession number Q8BR86-3)

Immunogen Species

Mouse

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2341106

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with other Kirrel3 isoforms

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

kin of IRRE like 3; Kin of IRRE-like protein 3; kin of irregular chiasm-like protein 3; Nephrin-like protein 2; NEPH2; mKirre [Cleaved into: Processed kin of IRRE-like protein 3; 1500010O20Rik; SST4; mKIAA1867; X kin of IRRE like 3; membrane protein mKirre

UniProt ID

Q8BR86
UniProt Summary: Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells.

NCBI Gene ID

67703

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Anti-Kirrel3 Short Isoform 3 Antibody (N320/48)

SKU: 75-282

Product Details

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