Anti-GluN2B/NR2B Glutamate Receptor Antibody FL550 Conjugate (N59/36)

Name: Anti-GluN2B/NR2B Glutamate Receptor Antibody FL550 Conjugate
Brand: NeuroMab
SKU: 75-101-FL550
Price: 543.0 USD
Availability: InStock

Our mouse GluN2B/NR2B glutamate receptor FL550 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N59/36. It detects human, mouse, and rat GluN2B/NR2B glutamate receptor and is purified by Protein A chromatography. Works in IHC, ICC.

Anti-GluN2B/NR2B Glutamate Receptor Antibody FL550 Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

594

650

Biotin

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-101-FL550

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

GluN2B/NR2B glutamate receptor

Scientific Background

GluN2B/NR2b glutamate receptor, also known as Glutamate/N-methyl D-aspartate/NMDA receptor subtype 2B, is a member of the NMDA receptor family. NMDA receptors are expressed throughout the CNS in postsynaptic cell membranes. GluN2B is a major NMDAR subtype found in cortical and hippocampal regions of the adult brain. NMDA receptors are involved with memory and learning. Mutations in the gene encoding GluN2B are associated with autism, LennoxGastaut and West Syndromes.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N59/36

Isotype

IgG2b

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Grin2b

Molecular Weight

166 kDa

Immunogen

Fusion protein amino acids 20-271 (extracellular N-terminus) of rat NR2B (accession number Q00960) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939377

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL550 Ex: 550 nm, Em: 575 nm

Specificity

Does not cross-react with GluN2A/NR2A

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

AW490526; Glutamate receptor ionotropic; EIEE27; GluN2B; Glutamate [NMDA receptor subunit epsilon 2; Glutamate [NMDA receptor subunit epsilon-2; Glutamate [NMDA receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; Glutamate Receptor Ionotropic N Methyl D Aspartate 2B; NMDAR2B; Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B; NR2B; Glutamate receptor ionotropic NMDA2B; Glutamate receptor subunit epsilon 2; Glutamate receptor ionotropic NMDA2B (epsilon 2; GRIN 2B; GRIN2B; hNR 3; hNR3; MGC142178; MGC142180; MRD6; N methyl D asparate receptor channel subunit epsilon 2; N methyl D aspartate receptor subtype 2B; N methyl D aspartate receptor subunit 2B; N methyl D aspartate receptor subunit 3; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3; NMDA NR2B; NMDA R2B; NMDAR2B; NMDE2; NMDE2_HUMAN; NME2; NR2B; NR3; NMDA 2B

UniProt ID

Q00960
UniProt Summary: Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation by contributing to the long-term depression (LTD) of hippocampus membrane currents. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death.

NCBI Gene ID

24410

Shipping

Shipped on ice packs

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Anti-GluN2B/NR2B Glutamate Receptor Antibody FL550 Conjugate (N59/36)

SKU: 75-101-FL550

Product Details

Bulk Order Anti-GluN2B/NR2B Glutamate Receptor Antibody FL550 Conjugate

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