Our mouse Cav1.3 Ca2+ channel monoclonal antibody from NeuroMab is produced in-house from clone L48A/9. It detects human, mouse, rabbit, and rat Cav1.3 Ca2+ channel and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.
Voltage-dependent L-type calcium channel subunit alpha-1D, or Cav1.3 calcium channel is a calcium channel encoded by the gene CACNA1D. It is a member of the L type voltage dependent calcium channel family. These calcium channels mediate the influx of calcium ions into a cell upon membrane polarization. Cav1.3 is expressed primarily in the membrane of the heart, brain (cerebral cortex, hippocampus, basal ganglia and thalamus). and pancreatic islets. Calcium channels are involved in many cell processes including muscle contraction, neurotransmitter release, gene expression, cell division and cell death. Diseases associated with Cav1.3 include Primary Aldosteronism, Seizures, Sinoatrial Node Dysfunction and Deafness.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
L48A/9
IgG2a
ELISA, ICC, IHC, WB
Mouse
Cacna1d Cach3 Cacn4 Cacnl1a2 Cchl1a2
250 kDa
Synthetic peptide amino acids 859-875 (N-terminus) of rat Cav1.3 (accession number P27732)
Rat
Human, Mouse, Rabbit, Rat
AB_2069388
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.41
Unconjugated
No cross-reactivity against Cav1.2
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
P27732
UniProt Summary: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines.
776
Shipped on ice packs
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