Anti-BKbeta4 K+ Channel Antibody (L18A/3)

Name: Anti-BKbeta4 K+ Channel Antibody
Brand: NeuroMab
SKU: 75-086
Price: 337.0 USD
Availability: InStock

Our mouse BKbeta4 K+ channel monoclonal antibody from NeuroMab is produced in-house from clone L18A/3. It detects human, mouse, and rat BKbeta4 K+ channel and is purified by Protein A chromatography. Works in WB, IHC, ICC, IP, ELISA.

Adult rat hippocampus immunohistochemistry.

Transfected cell immunoblot: extracts of COS-1 cells transiently transfected with BKBeta4 or Kv2.1 plasmids and probed with L18A/3 pure IgG at 10 mg/mL (left panel) or K89/41 TC supe (right panel).

Adult rat hippocampus immunohistochemistry.

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-086

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

BKbeta4 K+ channel

Scientific Background

Calcium-activated potassium channel subunit beta-4, Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 4 or BKBeta4 is encoded by the gene KCNMB4. BKbeta4 can bind to KCNMA1 to form a channel in the calcium activated large conductance (MaxiK channel) family. BKbeta4 acts to modulate the calcium sensitivity and gating kinetics of KCNMA1. It is expressed in brain and CNS.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L18A/3

Isotype

IgG2a

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Kcnmb4

Molecular Weight

24 kDa

Immunogen

Fusion protein amino acids 45-167 (entire extracellular domain) of mouse BKBeta4 (accession number Q9JIN6) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2131507

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.16

Dilution Ranges

WB: 1:500
ICC: 1:500

Conjugate

Unconjugated

Specificity

No cross-reactivity against BKBeta1, BKBeta2 or BKBeta3

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

1700058G18Rik; Calcium-activated potassium channel subunit beta-4; BK channel subunit beta-4; BKbeta4; Calcium-activated potassium channel; Slowpoke beta 4; Charybdotoxin receptor subunit beta-4; K(VCAbeta-4; Maxi K channel subunit beta-4; Slo-beta-4; subfamily M subunit beta-4

UniProt ID

Q9JIN6
UniProt Summary: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.

NCBI Gene ID

58802

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Anti-BKbeta4 K+ Channel Antibody (L18A/3)

SKU: 75-086

Product Details

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