Anti-BKbeta3a K+ Channel Antibody (N40B/18)

Name: Anti-BKbeta3a K+ Channel Antibody
Brand: NeuroMab
SKU: 75-098
Price: 337.0 USD
Availability: InStock

Our mouse BKbeta3a K+ channel monoclonal antibody from NeuroMab is produced in-house from clone N40B/18. It detects human, mouse, and rat BKbeta3a K+ channel and is purified by Protein A chromatography. Works in WB, IHC, IP, ELISA.

Adult rat hippocampus immunohistochemistry.

Immunoblot versus lysates of COS cells transiently transfected with BKBeta3a or Kv2.1 plasmids, probed with N40B/18 TC supe.

Immunoblot versus COS lysate and mouse brain membranes (MBM), probed with N40B/18 (left panel) and N89/34 (right panel) TC supe.

Adult rat hippocampus immunohistochemistry.

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-098

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

BKbeta3a K+ channel

Scientific Background

Calcium-activated potassium channel subunit beta-3, Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 3 or BKBeta3a is encoded by the gene KCNMB3. BKbeta3a can bind to KCNMA1 to form a channel in the calcium activated large conductance (MaxiK channel) family. BKbeta3a acts to modulate the calcium sensitivity and gating kinetics of KCNMA1. It is widely expressed in tissues, and is present in several isoforms. Diseases associated with this gene include Familial Febrile Seizures.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N40B/18

Isotype

IgG1

Applications

ELISA, IHC, IP, WB

Host Species

Mouse

Gene Name

Kcnmb3

Molecular Weight

32 kDa

Immunogen

Fusion protein amino acids 1-49 (unique N-terminus) of mouse BKBeta3a (accession number Q08460) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_10672110

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.25

Conjugate

Unconjugated

Specificity

No cross-reactivity against BKBeta1, BKBeta2, BKBeta3b or BKBeta4

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

5730414M22Rik; Potassium large conductance calcium-activated channel; MaxiK; Slo; Slo1; mSlo; mSlo1; BK channel alpha subunit; BKCA alpha; KCa1.1; k(VCAalpha; maxi K channel; slo homolog; slo-alpha; slowpoke homolog; subfamily M; beta member 3

UniProt ID

Q08460
UniProt Summary: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).

NCBI Gene ID

16531

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Anti-BKbeta3a K+ Channel Antibody (N40B/18)

SKU: 75-098

Product Details

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